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asm-3 Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase [ Caenorhabditis elegans ]

Gene ID: 176879, updated on 2-Nov-2024

Summary

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Official Symbol
asm-3
Official Full Name
Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase
Primary source
WormBase:WBGene00000213
Locus tag
CELE_W03G1.7
See related
AllianceGenome:WB:WBGene00000213
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acid sphingomyelin phosphodiesterase activity. Involved in lipid droplet disassembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asm-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (520214..523809, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PB1 domain-containing protein Neighboring gene Maternal embryonic leucine zipper kinase Neighboring gene ncRNA Neighboring gene Ribosomal RNA-processing protein 8 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos. Schmökel V, et al. Genetics, 2016 Mar. PMID 26773047, Free PMC Article
  2. The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging. Staab TA, et al. Aging (Albany NY), 2023 Feb 13. PMID 36787434, Free PMC Article
  3. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. Kim Y, et al. PLoS One, 2012. PMID 23049887, Free PMC Article
  4. Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Goya ME, et al. Cell Rep, 2020 Jan 14. PMID 31940482, Free PMC Article
  5. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos
    Title: Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
  2. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target
    Title: ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acid sphingomyelin phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid droplet disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase
NP_001040996.1
  • Confirmed by transcript evidence
NP_001040997.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    520214..523809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047531.2 → NP_001040996.1  Putative sphingomyelin phosphodiesterase asm-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9UAY4
    Conserved Domains (3) summary
    smart00741
    Location:20 → 92
    SapB; Saposin (B) Domains
    COG1409
    Location:208 → 462
    CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
    cd00842
    Location:135 → 439
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

  2. NM_001047532.6 → NP_001040997.1  Sphingomyelin phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040997.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY85
    Conserved Domains (3) summary
    smart00741
    Location:2 → 48
    SapB; Saposin (B) Domains
    cd00842
    Location:91 → 395
    MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    pfam00149
    Location:151 → 356
    Metallophos; Calcineurin-like phosphoesterase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UAY4.2

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