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nog-1 Nucleolar GTP-binding protein 1 [ Caenorhabditis elegans ]

Gene ID: 176863, updated on 2-Nov-2024

Summary

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Official Symbol
nog-1
Official Full Name
Nucleolar GTP-binding protein 1
Primary source
WormBase:WBGene00020297
Locus tag
CELE_T07A9.9
See related
AllianceGenome:WB:WBGene00020297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity and RNA binding activity. Involved in determination of adult lifespan; negative regulation of lipid storage; and regulation of reproductive process. Located in nucleolus. Is expressed in several structures, including excretory cell; germ cell; intestine; pharynx; and vulva. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nog-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (393880..396420)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sjogren's Syndrome Nuclear Autoantigen Neighboring gene Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial Neighboring gene Syntaxin-binding protein 1 Neighboring gene Cytochrome c oxidase assembly protein COX14 Neighboring gene Ribosomal RNA-processing protein 8 Neighboring gene Guanine nucleotide-binding protein alpha-4 subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. Zhu C, et al. Proc Natl Acad Sci U S A, 2018 Oct 2. PMID 30224484, Free PMC Article
  2. Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans. Kim YI, et al. Mol Cells, 2014 Jan. PMID 24552710, Free PMC Article
  3. rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans. Xu D, et al. Cell Rep, 2023 Aug 29. PMID 37537842
  4. Sperm chromatin proteomics identifies evolutionarily conserved fertility factors. Chu DS, et al. Nature, 2006 Sep 7. PMID 16943775, Free PMC Article
  5. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nog-1 in C. elegans may be an important player in regulating life span and fat storage via the insulin/IGF pathway.
    Title: Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid storage IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleolar GTP-binding protein 1
NP_741288.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    393880..396420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171242.6 → NP_741288.1  Nucleolar GTP-binding protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741288.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O44411, Q8MXI6
    Conserved Domains (3) summary
    cd01897
    Location:170 → 341
    NOG; Nucleolar GTP-binding protein (NOG)
    COG1084
    Location:3 → 346
    Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]
    pfam08155
    Location:445 → 495
    NOGCT; NOGCT (NUC087) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44411.1

Gene LinkOut

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