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mmad-1 Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176786, updated on 18-Sep-2024

Summary

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Official Symbol
mmad-1
Official Full Name
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
Primary source
WormBase:WBGene00013577
Locus tag
CELE_Y76A2B.5
See related
AllianceGenome:WB:WBGene00013577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in cobalamin metabolic process. Predicted to be active in mitochondrion. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mmad-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (13546889..13549005, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Long-chain-fatty-acid--CoA ligase Neighboring gene Uncharacterized protein Neighboring gene SCAVenger receptor (CD36 family) related Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cobalamin metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
NP_499801.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    13546889..13549005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067400.12 → NP_499801.1  Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499801.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWC9
    Conserved Domains (1) summary
    pfam10229
    Location:5 → 274
    DUF2246; Uncharacterized conserved protein (DUF2246)
Nucleotide Protein
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