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hpl-2 Chromobox protein homolog hpl-2 [ Caenorhabditis elegans ]

Gene ID: 176506, updated on 2-Nov-2024

Summary

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Official Symbol
hpl-2
Official Full Name
Chromobox protein homolog hpl-2
Primary source
WormBase:WBGene00001996
Locus tag
CELE_K01G5.2
See related
AllianceGenome:WB:WBGene00001996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables H3K27me3 modified histone binding activity and chromatin binding activity. Involved in several processes, including nematode larval development; regulation of gene expression; and reproductive structure development. Located in nuclear periphery. Is expressed widely. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hpl-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (10752195..10755530, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative H/ACA ribonucleoprotein complex subunit 4 Neighboring gene ENhancer of Uncoordination Neighboring gene putative E3 ubiquitin-protein ligase rnf113 Neighboring gene Haloacid dehalogenase-like hydrolase domain-containing protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells. Schott S, et al. Genetics, 2009 Feb. PMID 19064713, Free PMC Article
  2. The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development. Coustham V, et al. Dev Biol, 2006 Sep 15. PMID 16890929
  3. Perinuclear distribution of heterochromatin in developing C. elegans embryos. Grant J, et al. Chromosome Res, 2010 Dec. PMID 21116703
  4. Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Black JC, et al. Mol Cell, 2010 Dec 10. PMID 21145482
  5. Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos. Yuen KW, et al. Curr Biol, 2011 Nov 8. PMID 22018540, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
    Title: Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
  2. As nuclear RNAi involves chromatin changes moderated by HPL-2, a homolog of heterochromatin protein 1 (HP1), we investigated the interaction of TDP-1 and HPL-2. We found that TDP-1 and HPL-2 interact directly and that loss of TDP-1 dramatically alters the chromatin association of HPL-2.
    Title: The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
  3. At the genic level, HPL-2 preferentially associates with well-expressed genes, and loss of HPL-2 results in up-regulation of some binding targets and down-regulation of others.
    Title: Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.
  4. Caenorhabditis elegans heterochromatin protein like-2 (HPL-2), the homolog of heterochromatin protein 1 (HP1), down-regulates the unfolded protein response in the intestine.
    Title: The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.
  5. The heterochromatin protein 1 family proteins HPL-1 and HPL-2 are dispensable for de novo centromerization even though arrays become strongly enriched for the heterochromatin-associated H3K9me3 modification over time.
    Title: Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
  6. Caenorhabditis elegans HPL-2 links developmental plasticity, longevity and lipid metabolism.
    Title: Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
  7. Caenorhabditis elegans H1 variant his-24, hpl-1, and hpl-2 coregulate the expression of genes linked to immune response.
    Title: Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
  8. the SynMuv gene hpl-2/HP1 has an additional function in vulva precursor cells, where it may act through target genes including LIN-39/Hox
    Title: HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
  9. the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin
    Title: The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
  10. Our results show that HPL-1 and HPL-2 play both unique and redundant functions in post-embryonic development.
    Title: Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables H3K27me3 modified histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome attachment to the nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome attachment to the nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail mating organ morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in olfactory learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of growth rate IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vulval cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chromobox protein homolog hpl-2
NP_001022652.1
  • Confirmed by transcript evidence
NP_001022653.1
  • Confirmed by transcript evidence
NP_001022654.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10752195..10755530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027482.4 → NP_001022653.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFS9
    Conserved Domains (2) summary
    cd18960
    Location:18 → 68
    CD_HP1_like; chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup
    cl28914
    Location:109 → 153
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  2. NM_001027483.3 → NP_001022654.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3C6
    Conserved Domains (2) summary
    cd18960
    Location:18 → 68
    CD_HP1_like; chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup
    cl28914
    Location:109 → 153
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  3. NM_001027481.5 → NP_001022652.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022652.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDE2, G5EFS9, Q9U3C6
    Conserved Domains (2) summary
    smart00300
    Location:109 → 169
    ChSh; Chromo Shadow Domain
    cl28914
    Location:18 → 68
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
Nucleotide Protein
Heading Accession and Version

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