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unc-69 Short coiled-coil protein;Short coiled-coil protein homolog [ Caenorhabditis elegans ]

Gene ID: 176444, updated on 18-Sep-2024

Summary

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Official Symbol
unc-69
Official Full Name
Short coiled-coil protein;Short coiled-coil protein homolog
Primary source
WormBase:WBGene00006802
Locus tag
CELE_T07A5.6
See related
AllianceGenome:WB:WBGene00006802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in ganglia; neurons; and somatic nervous system. Orthologous to human SCOC (short coiled-coil protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See unc-69 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (10318939..10320019)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein unc-50 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Spindle assembly abnormal protein 7 Neighboring gene Annexin Neighboring gene COMM domain-containing protein Neighboring gene JmjC domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy. Joachim J, et al. Autophagy, 2012 Sep. PMID 22717455, Free PMC Article
  2. Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity. Teixeira MB, et al. World J Biol Chem, 2019 Feb 21. PMID 30815230, Free PMC Article
  3. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Hengartner MO, et al. Cell, 1994 Feb 25. PMID 7907274
  4. Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans. Kodoyianni V, et al. Mol Biol Cell, 1992 Nov. PMID 1457827, Free PMC Article
  5. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Kinchen JM, et al. Nature, 2005 Mar 3. PMID 15744306

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Short coiled-coil protein;Short coiled-coil protein homolog
NP_001022752.1
  • Confirmed by transcript evidence
NP_001022753.1
  • Confirmed by transcript evidence
NP_001122717.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10318939..10320019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027581.5 → NP_001022752.1  Short coiled-coil protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U377
    Conserved Domains (1) summary
    pfam10224
    Location:46 → 92
    DUF2205; Predicted coiled-coil protein (DUF2205)

  2. NM_001027582.4 → NP_001022753.1  Short coiled-coil protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDQ5
    Conserved Domains (1) summary
    pfam10224
    Location:46 → 92
    DUF2205; Predicted coiled-coil protein (DUF2205)

  3. NM_001129245.5 → NP_001122717.1  Short coiled-coil protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122717.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A7LPF8
    Conserved Domains (1) summary
    pfam10224
    Location:46 → 92
    DUF2205; Predicted coiled-coil protein (DUF2205)
Nucleotide Protein
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