ZK632.4 putative mannose-6-phosphate isomerase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK632.4
Official Full Name: putative mannose-6-phosphate isomerase
Primary source: WormBase:WBGene00014013
Locus tag: CELE_ZK632.4
See related: AllianceGenome:WB:WBGene00014013
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ZK632.4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (9805515..9807454, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK632.4 (e-PCR)
- UniSTS:308288

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables mannose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-6-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative mannose-6-phosphate isomerase

NP_499174.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9805515..9807454 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066773.7 → NP_499174.3 putative mannose-6-phosphate isomerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499174.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P34650

Conserved Domains (2) summary

COG1482
Location:1 → 400

ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]

pfam01238
Location:2 → 363

PMI_typeI; Phosphomannose isomerase type I