ZK370.4 Patatin-like phospholipase domain-containing protein ZK370.4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ZK370.4
Official Full Name: Patatin-like phospholipase domain-containing protein ZK370.4
Primary source: WormBase:WBGene00022718
Locus tag: CELE_ZK370.4
See related: AllianceGenome:WB:WBGene00022718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lysophospholipase activity. Predicted to be involved in lipid catabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to several human genes including PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ZK370.4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 17

Sequence:: Chromosome: III; NC_003281.10 (8725316..8731410, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ZK370.4 (e-PCR)
- UniSTS:310476

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Patatin-like phospholipase domain-containing protein ZK370.4

NP_498926.2

Confirmed by transcript evidence

NP_498927.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8725316..8731410 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066525.3 → NP_498926.2 Patatin-like phospholipase domain-containing protein ZK370.4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498926.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02331

Conserved Domains (4) summary

COG0664
Location:572 → 689

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:939 → 1218

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:567 → 675

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl11396
Location:915 → 1201

Patatin_and_cPLA2; Patatins and Phospholipases
NM_066526.6 → NP_498927.2 Patatin-like phospholipase domain-containing protein ZK370.4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498927.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02331, Q6LDE9, Q6LDF0, Q95PX1

Conserved Domains (4) summary

COG0664
Location:583 → 700

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

COG1752
Location:950 → 1229

RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]

cd00038
Location:578 → 686

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cl11396
Location:926 → 1212

Patatin_and_cPLA2; Patatins and Phospholipases