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ZK1236.1 Translation factor GUF1 homolog, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176191, updated on 18-Sep-2024

Summary

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Official Symbol
ZK1236.1
Official Full Name
Translation factor GUF1 homolog, mitochondrial
Primary source
WormBase:WBGene00022862
Locus tag
CELE_ZK1236.1
See related
AllianceGenome:WB:WBGene00022862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ZK1236.1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (8429297..8431621)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Chromo domain-containing protein cec-1 Neighboring gene Uncharacterized protein Neighboring gene TPR_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitochondrial ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Translation factor GUF1 homolog, mitochondrial
NP_498863.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    8429297..8431621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066462.5 → NP_498863.1  Translation factor GUF1 homolog, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34617
    Conserved Domains (6) summary
    cd01890
    Location:43 → 214
    LepA; LepA also known as Elongation Factor 4 (EF4)
    PRK05433
    Location:39 → 644
    PRK05433; GTP-binding protein LepA; Provisional
    cd03709
    Location:445 → 523
    lepA_C; lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits ...
    pfam06421
    Location:532 → 644
    LepA_C; GTP-binding protein LepA C-terminus
    cd03699
    Location:222 → 305
    EF4_II; Domain II of Elongation Factor 4 (EF4)
    cd16260
    Location:326 → 401
    EF4_III; Domain III of Elongation Factor 4 (EF4)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34617.2

Gene LinkOut

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