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upp-1 Uridine and thymidine phosphorylase [ Caenorhabditis elegans ]

Gene ID: 176077, updated on 28-Oct-2024

Summary

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Official Symbol
upp-1
Official Full Name
Uridine and thymidine phosphorylase
Primary source
WormBase:WBGene00022817
Locus tag
CELE_ZK783.2
See related
AllianceGenome:WB:WBGene00022817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables thymidine phosphorylase activity and uridine phosphorylase activity. Involved in thymidine metabolic process; uracil catabolic process; and uridine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in gonad; hypodermis; and pharynx. Orthologous to human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See upp-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7641034..7643101, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A forward genetic approach for analyzing the mechanism of resistance to the anti-cancer drug, 5-fluorouracil, using Caenorhabditis elegans. Kim S, et al. Mol Cells, 2008 Feb 29. PMID 18319623
  2. Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans. Kim S, et al. FEBS J, 2009 Sep. PMID 19645718
  3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyuridine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables thymidine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thymidine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine phosphorylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thymidine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uracil metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uridine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uridine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uridine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Uridine and thymidine phosphorylase
NP_498671.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7641034..7643101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066270.7 → NP_498671.2  Uridine and thymidine phosphorylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498671.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23588
    Conserved Domains (1) summary
    cl00303
    Location:14 → 295
    PNP_UDP_1; Phosphorylase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23588.2

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