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fum-1 putative fumarate hydratase, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 176059, updated on 18-Sep-2024

Summary

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Official Symbol
fum-1
Official Full Name
putative fumarate hydratase, mitochondrial
Primary source
WormBase:WBGene00001503
Locus tag
CELE_H14A12.2
See related
AllianceGenome:WB:WBGene00001503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See fum-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (7465605..7467640)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Protein rogdi homolog Neighboring gene ncRNA Neighboring gene tRNA-synt_2 domain-containing protein Neighboring gene Transmembrane matrix receptor MUP-4 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Joint mouse-human phenome-wide association to test gene function and disease risk. Wang X, et al. Nat Commun, 2016 Feb 2. PMID 26833085, Free PMC Article
  2. Oligonucleotide Array Comparative Genomic Hybridization (oaCGH) based characterization of genetic deficiencies as an aid to gene mapping in Caenorhabditis elegans. Jones MR, et al. BMC Genomics, 2007 Nov 7. PMID 17986355, Free PMC Article
  3. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Yoneda T, et al. J Cell Sci, 2004 Aug 15. PMID 15280428
  4. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  5. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fumarate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fumarate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fumarate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fumarate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative fumarate hydratase, mitochondrial
NP_498642.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    7465605..7467640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066241.8 → NP_498642.1  putative fumarate hydratase, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498642.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17214
    Conserved Domains (2) summary
    cd01362
    Location:42 → 497
    Fumarase_classII; Class II fumarases
    PRK00485
    Location:38 → 501
    fumC; fumarate hydratase; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17214.1

Gene LinkOut

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