panl-2 PAN (PolyA-specific riboNucLease) subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: panl-2
Official Full Name: PAN (PolyA-specific riboNucLease) subunit
Primary source: WormBase:WBGene00017951
Locus tag: CELE_F31E3.4
See related: AllianceGenome:WB:WBGene00017951
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleic acid binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be part of PAN complex. Predicted to be active in P-body. Is expressed in intestine; nervous system; and pharynx. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See panl-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (6963620..6968130, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F31E3.4 (e-PCR)
- UniSTS:310050

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
contributes_to poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
part_of PAN complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PAN (PolyA-specific riboNucLease) subunit

NP_498519.1

Product from WormBase gene class panl;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6963620..6968130 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066118.6 → NP_498519.1 PAN (PolyA-specific riboNucLease) subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498519.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P53015

Conserved Domains (4) summary

cd06143
Location:909 → 1075

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

COG2319
Location:17 → 322

WD40; WD40 repeat [General function prediction only]

cl02553
Location:493 → 613

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl02567
Location:28 → 324

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...