pdfr-1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pdfr-1
Official Full Name: Calcitonin receptor-like protein 1
Primary source: WormBase:WBGene00015735
Locus tag: CELE_C13B9.4
See related: AllianceGenome:WB:WBGene00015735
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcitonin family receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; locomotion involved in locomotory behavior; and locomotory exploration behavior. Located in plasma membrane. Is expressed in several structures, including body wall musculature; nerve ring; neurons; outer labial lateral sensillum; and vulD. Human ortholog(s) of this gene implicated in bone disease (multiple); hereditary lymphedema; and primary failure of tooth eruption. Orthologous to human CALCR (calcitonin receptor); CALCRL (calcitonin receptor like receptor); and PTH1R (parathyroid hormone 1 receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pdfr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (6632841..6651031, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior.
Title: Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior.
In Drosophila, the ion channel narrow abdomen, an ortholog of the C. elegans NCA channels, drive the pigment dispersing factor (PDF) neuropeptide release, regulating circadian behavior. However, in C. elegans, we found that loss of the PDF receptor PDFR-1 did not suppress gain-of-function sleep defects, suggesting an alternative downstream pathway.
Title: Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans.
The PDFR-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior.
Title: PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.
The pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant.
Title: PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13B9.4 (e-PCR)
- UniSTS:309055

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin family receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcitonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Calcitonin receptor-like protein 1

NP_001021170.1

Confirmed by transcript evidence

NP_001021171.1

Confirmed by transcript evidence

NP_001293621.1

Confirmed by transcript evidence

NP_001360187.1

Confirmed by transcript evidence

NP_001370425.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6632841..6651031 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025999.5 → NP_001021170.1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021170.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2BBX5, G5EDW6, G5EFM1, Q09460

Conserved Domains (2) summary

pfam00002
Location:164 → 425

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:74 → 143

HRM; Hormone receptor domain
NM_001372610.3 → NP_001360187.1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

S6F595

Conserved Domains (2) summary

smart00008
Location:70 → 148

HormR; Domain present in hormone receptors

cd15261
Location:154 → 436

7tmB1_PDFR; The pigment dispersing factor receptor, member of the class B seven-transmembrane G protein-coupled receptors
NM_001306692.3 → NP_001293621.1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293621.1

Status: REVIEWED

UniProtKB/TrEMBL

S6FD44

Conserved Domains (2) summary

smart00008
Location:70 → 148

HormR; Domain present in hormone receptors

pfam00002
Location:154 → 415

7tm_2; 7 transmembrane receptor (Secretin family)
NM_001382898.2 → NP_001370425.1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

smart00008
Location:70 → 140

HormR; Domain present in hormone receptors

cd15261
Location:164 → 446

7tmB1_PDFR; The pigment dispersing factor receptor, member of the class B seven-transmembrane G protein-coupled receptors
NM_001026000.5 → NP_001021171.1 Calcitonin receptor-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021171.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09460

Conserved Domains (2) summary

smart00008
Location:70 → 148

HormR; Domain present in hormone receptors

pfam00002
Location:154 → 415

7tm_2; 7 transmembrane receptor (Secretin family)