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aldo-2 Fructose-bisphosphate aldolase 2 [ Caenorhabditis elegans ]

Gene ID: 175827, updated on 2-Nov-2024

Summary

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Official Symbol
aldo-2
Official Full Name
Fructose-bisphosphate aldolase 2
Primary source
WormBase:WBGene00017166
Locus tag
CELE_F01F1.12
See related
AllianceGenome:WB:WBGene00017166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fructose-bisphosphate aldolase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Predicted to be located in cytoplasm and heterochromatin. Predicted to be active in cytosol. Is expressed widely. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system. Orthologous to human ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aldo-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (5874678..5876470, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF3456 domain-containing protein Neighboring gene PAP-associated domain-containing protein Neighboring gene MIF4G domain-containing protein Neighboring gene Abnormal cell migration protein 21 Neighboring gene ncRNA Neighboring gene COX assembly mitochondrial protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolic enzymes aldo-2 and pdhb-1 as potential epigenetic regulators during C. elegans embryogenesis. Ravanelli S, et al. MicroPubl Biol, 2024. PMID 38947245, Free PMC Article
  2. The effects of plant cysteine proteinases on the nematode cuticle. Njom VS, et al. Parasit Vectors, 2021 Jun 5. PMID 34090505, Free PMC Article
  3. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
  4. Evidence of glutathione transferase complexing and signaling in the model nematode Caenorhabditis elegans using a pull-down proteomic assay. Greetham D, et al. Proteomics, 2004 Jul. PMID 15221760
  5. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose-bisphosphate aldolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Fructose-bisphosphate aldolase 2
NP_001021240.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5874678..5876470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026069.8 → NP_001021240.1  Fructose-bisphosphate aldolase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P46563
    Conserved Domains (1) summary
    pfam00274
    Location:19 → 366
    Glycolytic; Fructose-bisphosphate aldolase class-I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46563.1

Gene LinkOut

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