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morc-1 ATPase morc-1 [ Caenorhabditis elegans ]

Gene ID: 175711, updated on 28-Oct-2024

Summary

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Official Symbol
morc-1
Official Full Name
ATPase morc-1
Primary source
WormBase:WBGene00022531
Locus tag
CELE_ZC155.3
See related
AllianceGenome:WB:WBGene00022531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables topological DNA co-entrapment activity. Involved in DNA topological change. Located in nuclear body. Is expressed in germ line and somatic cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to several human genes including MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See morc-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
8
Sequence:
Chromosome: III; NC_003281.10 (5203685..5206911, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein HIRA;Protein HIRA-like C-terminal domain-containing protein Neighboring gene Molybdopterin synthase sulfur carrier subunit Neighboring gene NADPH--cytochrome P450 reductase Neighboring gene t-SNARE coiled-coil homology domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction. Kim H, et al. Mol Cell, 2019 Aug 22. PMID 31442422, Free PMC Article
  2. MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality. Weiser NE, et al. Dev Cell, 2017 May 22. PMID 28535375, Free PMC Article
  3. The RNAi Inheritance Machinery of Caenorhabditis elegans. Spracklin G, et al. Genetics, 2017 Jul. PMID 28533440, Free PMC Article
  4. Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins SET-25 and SET-32. Woodhouse RM, et al. Epigenet Insights, 2019. PMID 31020270, Free PMC Article
  5. The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans. Araoi S, et al. J Biochem, 2018 May 1. PMID 29361115

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that MORCs affect genome structure and gene silencing by forming multimeric assemblages to topologically entrap and progressively loop and compact chromatin.
    Title: The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.
  2. morc-1 is essential for transgenerational fertility and acts as an effector of endo-siRNAs.
    Title: MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables topological DNA co-entrapment activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATPase morc-1
NP_498104.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5203685..5206911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065703.7 → NP_498104.1  ATPase morc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23243
    Conserved Domains (1) summary
    cl00075
    Location:31 → 137
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23243.2

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