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dpy-27 Chromosome condensation protein dpy-27 [ Caenorhabditis elegans ]

Gene ID: 175492, updated on 18-Sep-2024

Summary

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Official Symbol
dpy-27
Official Full Name
Chromosome condensation protein dpy-27
Primary source
WormBase:WBGene00001086
Locus tag
CELE_R13G10.1
See related
AllianceGenome:WB:WBGene00001086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in dosage compensation by hypoactivation of X chromosome. Located in X chromosome and nuclear chromosome. Part of dosage compensation complex. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See dpy-27 in Genome Data Viewer
Location:
chromosome: III
Exon count:
12
Sequence:
Chromosome: III; NC_003281.10 (3813018..3819679, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene X-BoX promoter element regulated Neighboring gene Zinc metalloproteinase nas-26 Neighboring gene ncRNA Neighboring gene Lysine-specific histone demethylase 1B homolog Neighboring gene Metal transporter cnnm-5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic bias in high-throughput sequencing data and its correction by BEADS. Cheung MS, et al. Nucleic Acids Res, 2011 Aug. PMID 21646344, Free PMC Article
  2. The Caenorhabditis elegans dosage compensation machinery is recruited to X chromosome DNA attached to an autosome. Lieb JD, et al. Genetics, 2000 Dec. PMID 11102361, Free PMC Article
  3. DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. Chuang PT, et al. Cell, 1994 Nov 4. PMID 7954812
  4. The genomic distribution and function of histone variant HTZ-1 during C. elegans embryogenesis. Whittle CM, et al. PLoS Genet, 2008 Sep 12. PMID 18787694, Free PMC Article
  5. X chromosome repression by localization of the C. elegans dosage compensation machinery to sites of transcription initiation. Ercan S, et al. Nat Genet, 2007 Mar. PMID 17293863, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in dosage compensation by hypoactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dosage compensation complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chromosome condensation protein dpy-27
NP_497771.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    3813018..3819679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065370.7 → NP_497771.1  Chromosome condensation protein dpy-27 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48996
    Conserved Domains (3) summary
    COG1196
    Location:91 → 1322
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06470
    Location:620 → 736
    SMC_hinge; SMC proteins Flexible Hinge Domain
    cl21455
    Location:1235 → 1331
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48996.1

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