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Mrc2 mannose receptor, C type 2 [ Mus musculus (house mouse) ]

Gene ID: 17534, updated on 2-Nov-2024

Summary

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Official Symbol
Mrc2provided by MGI
Official Full Name
mannose receptor, C type 2provided by MGI
Primary source
MGI:MGI:107818
See related
Ensembl:ENSMUSG00000020695 AllianceGenome:MGI:107818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
uPARAP; Endo180; mKIAA0709
Summary
Predicted to enable carbohydrate binding activity; collagen binding activity; and signaling receptor activity. Predicted to be involved in collagen catabolic process. Predicted to be located in cell surface. Is expressed in several structures, including brain; head bone; meninges; metanephros; and respiratory system. Orthologous to human MRC2 (mannose receptor C-type 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 31.6), lung adult (RPKM 31.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Mrc2 in Genome Data Viewer
Location:
11 E1; 11 68.73 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105183440..105241971)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105292093..105351146)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700052K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E8463 Neighboring gene tousled-like kinase 2 (Arabidopsis) Neighboring gene STARR-seq mESC enhancer starr_30905 Neighboring gene predicted gene, 53649 Neighboring gene STARR-positive B cell enhancer mm9_chr11:105209236-105209536 Neighboring gene uncharacterized LOC115487808 Neighboring gene membrane associated ring-CH-type finger 10 Neighboring gene predicted gene, 39417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome. Potter AS, et al. Circ Genom Precis Med, 2024 Aug. PMID 38953222,
  2. Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. Curino AC, et al. J Cell Biol, 2005 Jun 20. PMID 15967816, Free PMC Article
  3. Role of urokinase plasminogen activator receptor-associated protein in mouse lung. Bundesmann MM, et al. Am J Respir Cell Mol Biol, 2012 Feb. PMID 21940816, Free PMC Article
  4. Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis. Madsen DH, et al. J Pathol, 2012 May. PMID 22294280
  5. uPARAP function in cutaneous wound repair. Rohani MG, et al. PLoS One, 2014. PMID 24663959, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome.
    Title: Rare Variant in MRC2 Associated With Familial Supraventricular Tachycardia and Wolff-Parkinson-White Syndrome.
  2. The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
    Title: The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
  3. Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.
    Title: Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis.
  4. MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/beta-catenin signaling pathway.
    Title: MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the Wnt/β-catenin signaling pathway.
  5. Fibroblast-specific expression of uPARAP governed endogenous SP-D levels and overall survival after lung injury.
    Title: Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
  6. uPARAP controlVEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
    Title: uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
  7. Findings show that under in vivo conditions, uPARAP does not play a role in the phagocytic uptake of collagen fibrils by fibroblasts.
    Title: Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo Is Independent of the uPARAP/Endo180 Receptor.
  8. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma
    Title: Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
  9. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.
    Title: AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
  10. uPARAP function in cutaneous wound repair
    Title: uPARAP function in cutaneous wound repair.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141530

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-type mannose receptor 2
Names
lectin lambda
macrophage mannose receptor 2
novel lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008626.3 → NP_032652.3  C-type mannose receptor 2 precursor

    See identical proteins and their annotated locations for NP_032652.3

    Status: VALIDATED

    Source sequence(s)
    AL645684, BB665946, BC116642, BU053305
    Consensus CDS
    CCDS25539.1
    UniProtKB/Swiss-Prot
    A2AAB0, Q64449, Q6ZQ64, Q8C6P0
    UniProtKB/TrEMBL
    Q14AX9
    Related
    ENSMUSP00000097909.4, ENSMUST00000100335.10
    Conserved Domains (4) summary
    smart00059
    Location:179 → 227
    FN2; Fibronectin type 2 domain
    cd00037
    Location:246 → 360
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:381 → 504
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:45 → 160
    RICIN; Ricin-type beta-trefoil

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105183440..105241971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532406.5 → XP_006532469.1  C-type mannose receptor 2 isoform X1

    UniProtKB/TrEMBL
    Q14AX9
    Conserved Domains (4) summary
    smart00059
    Location:214 → 262
    FN2; Fibronectin type 2 domain
    cd00037
    Location:281 → 395
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:416 → 539
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    smart00458
    Location:80 → 195
    RICIN; Ricin-type beta-trefoil
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64449.3 GenPept UniProtKB/Swiss-Prot:Q64449

Gene LinkOut

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