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sucl-2 Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 175252, updated on 28-Oct-2024

Summary

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Official Symbol
sucl-2
Official Full Name
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Primary source
WormBase:WBGene00017759
Locus tag
CELE_F23H11.3
See related
AllianceGenome:WB:WBGene00017759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable succinate-CoA ligase (ADP-forming) activity and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in tricarboxylic acid cycle. Predicted to be part of succinate-CoA ligase complex (ADP-forming). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See sucl-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
3
Sequence:
Chromosome: III; NC_003281.10 (900138..901412, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene C2H2-type domain-containing protein Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene Rho-GAP domain-containing protein Neighboring gene putative cardiolipin synthase (CMP-forming)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Tischler J, et al. Genome Biol, 2006. PMID 16884526, Free PMC Article
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of succinate-CoA ligase complex (ADP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
NP_497288.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    900138..901412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064887.8 → NP_497288.1  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497288.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02642
    Conserved Domains (3) summary
    PTZ00187
    Location:19 → 319
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    pfam02629
    Location:32 → 125
    CoA_binding; CoA binding domain
    cl22543
    Location:178 → 303
    Ligase_CoA; CoA-ligase
Nucleotide Protein
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