algn-8 Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: algn-8
Official Full Name: Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Primary source: WormBase:WBGene00007464
Locus tag: CELE_C08H9.3
See related: AllianceGenome:WB:WBGene00007464
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See algn-8 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 13

Sequence:: Chromosome: II; NC_003280.10 (9882730..9886442, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08H9.3 (e-PCR)
- UniSTS:306151

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

NP_001021940.2

Confirmed by transcript evidence

NP_001379427.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9882730..9886442 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026769.6 → NP_001021940.2 Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021940.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P52887, Q5WRQ2

Conserved Domains (2) summary

cd06559
Location:513 → 753

Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

pfam03155
Location:15 → 496

Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
NM_001393171.1 → NP_001379427.1 Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl21590
Location:15 → 112

PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase