fzr-1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fzr-1
Official Full Name: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
Primary source: WormBase:WBGene00001510
Locus tag: CELE_ZK1307.6
See related: AllianceGenome:WB:WBGene00001510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in cell cycle G1/S phase transition and regulation of cell division. Located in cytoplasm and nucleus. Is expressed in intestinal cell; seam cell; ventral cord blast cell; and vulval precursor cell. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See fzr-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (9640156..9644466, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.
Title: APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.
Our data suggest that the APC/C(FZR-1) regulates SAS-5 levels by directly recognizing the conserved KEN-box motif, contributing to proper centrosome duplication. Together, our work shows that FZR-1 plays a conserved role in regulating centrosome duplication in C. elegans
Title: APC/C(FZR-1) Controls SAS-5 Levels To Regulate Centrosome Duplication in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1307.6 (e-PCR)
- UniSTS:308257

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle G1/S phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein

NP_001382697.1

Partially confirmed by transcript evidence

NP_496075.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

9640156..9644466 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063674.7 → NP_496075.1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496075.1

Status: REVIEWED

UniProtKB/TrEMBL

Q09649

Conserved Domains (2) summary

cd00200
Location:400 → 679

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:441 → 478

7WD40; WD40 repeat [structural motif]
NM_001395804.1 → NP_001382697.1 Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A7R9SW82

Conserved Domains (2) summary

cd00200
Location:400 → 681

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:441 → 478

7WD40; WD40 repeat [structural motif]