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ifg-1 MIF4G domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 174322, updated on 2-Nov-2024

Summary

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Official Symbol
ifg-1
Official Full Name
MIF4G domain-containing protein
Primary source
WormBase:WBGene00002066
Locus tag
CELE_M110.4
See related
AllianceGenome:WB:WBGene00002066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ifg-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (8217222..8222396)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein 15 Neighboring gene E3 ubiquitin-protein ligase MARCHF5 Neighboring gene ncRNA Neighboring gene PID domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene Putative patatin-like phospholipase domain-containing protein M110.7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans. Contreras V, et al. Cell Death Differ, 2008 Aug. PMID 18451872
  2. The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs. Wallace A, et al. Mol Cell Biol, 2010 Apr. PMID 20154140, Free PMC Article
  3. A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging. Adamla F, et al. Cell Physiol Biochem, 2019. PMID 30977983, Free PMC Article
  4. Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism. Contreras V, et al. PLoS One, 2011. PMID 21909434, Free PMC Article
  5. Translational suppression via IFG-1/eIF4G inhibits stress-induced RNA alternative splicing in Caenorhabditis elegans. Chomyshen SC, et al. Genetics, 2022 Jul 4. PMID 35536193, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IFG-1 mediates the antagonistic effects on growth and somatic maintenance by regulating mRNA translation of particular mRNAs based on transcript length.
    Title: Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
  2. Data suggest that mRNA 5' untranslated regions affect translation initiation through interaction with eIF4E/G in nematodes and raise the issue of whether eIF4E/G-RNA interactions play a role in the translation of other eukaryotic mRNAs.
    Title: The nematode eukaryotic translation initiation factor 4E/G complex works with a trans-spliced leader stem-loop to enable efficient translation of trimethylguanosine-capped RNAs.
  3. eIF4G isoforms are differentially utilized during oogenesis to regulate germ cell apoptosis. We propose that an alternative mechanism to eIF4G cleavage may be employed in germ cells by changing the availability of the p170 isoform.
    Title: Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 4F complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MIF4G domain-containing protein
NP_001022259.1
  • Confirmed by transcript evidence
NP_001022260.1
  • Confirmed by transcript evidence
NP_001359723.1
  • Confirmed by transcript evidence
NP_001368728.1
  • Confirmed by transcript evidence
NP_001379490.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8217222..8222396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393134.1 → NP_001379490.1  MIF4G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM23
    Conserved Domains (2) summary
    pfam02854
    Location:404 → 634
    MIF4G; MIF4G domain
    NF033761
    Location:113 → 225
    gliding_GltJ; adventurous gliding motility protein GltJ

  2. NM_001373755.2 → NP_001359723.1  MIF4G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM24
    Conserved Domains (1) summary
    pfam02854
    Location:521 → 751
    MIF4G; MIF4G domain

  3. NM_001027088.8 → NP_001022259.1  MIF4G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21531
    Conserved Domains (1) summary
    pfam02854
    Location:518 → 748
    MIF4G; MIF4G domain

  4. NM_001027089.7 → NP_001022260.1  MIF4G domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMF0
    Conserved Domains (1) summary
    pfam02854
    Location:517 → 747
    MIF4G; MIF4G domain

  5. NM_001381521.1 → NP_001368728.1  MIF4G domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WX07
    Conserved Domains (2) summary
    pfam02854
    Location:522 → 752
    MIF4G; MIF4G domain
    NF033761
    Location:231 → 343
    gliding_GltJ; adventurous gliding motility protein GltJ
Nucleotide Protein
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