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pde-4 Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [ Caenorhabditis elegans ]

Gene ID: 174235, updated on 14-Nov-2024

Summary

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Official Symbol
pde-4
Official Full Name
Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4
Primary source
WormBase:WBGene00020114
Locus tag
CELE_R153.1
See related
AllianceGenome:WB:WBGene00020114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and sleep. Located in synapse. Is expressed in neurons. Human ortholog(s) of this gene implicated in acrodysostosis and alcohol dependence. Orthologous to several human genes including PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pde-4 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (7627250..7651246, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ALS/FTD Associated gene homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lifespan extension in Caenorhabditis elegans by oxyresveratrol supplementation in hyper-branched cyclodextrin-based nanosponges. Matencio A, et al. Int J Pharm, 2020 Nov 15. PMID 32916214
  2. EGL-4 promotes turning behavior of C. elegans males during mating. Rahmani S, et al. MicroPubl Biol, 2021. PMID 34423280, Free PMC Article
  3. Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons. Yu B, et al. Dev Cell, 2017 Oct 23. PMID 29033363
  4. Lethargus is a Caenorhabditis elegans sleep-like state. Raizen DM, et al. Nature, 2008 Jan 31. PMID 18185515
  5. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function and neural overexpression of PDE-4 have profound and opposite effects on locomotion rate, but drug-response assays suggest that loss of PDE-4 function does not affect steady-state acetylcholine release or reception.
    Title: The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Phosphodiesterase;putative 3',5'-cyclic-AMP phosphodiesterase pde-4
NP_001040798.1
  • Confirmed by transcript evidence
NP_001293472.1
  • Confirmed by transcript evidence
NP_001379885.1
  • Confirmed by transcript evidence
NP_001379886.1
  • Confirmed by transcript evidence
NP_495600.1
  • Confirmed by transcript evidence
NP_495601.1
  • Confirmed by transcript evidence
NP_871945.1
  • Confirmed by transcript evidence
NP_871947.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7627250..7651246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393119.1 → NP_001379885.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam00233
    Location:344 → 585
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:95 → 211
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. NM_182145.6 → NP_871945.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871945.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000, Q86NE7, Q86NE8, Q86NE9, Q8IFZ3, Q95ZQ6
    Conserved Domains (1) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  3. NM_063200.5 → NP_495601.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495601.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:281 → 522
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  4. NM_001047333.6 → NP_001040798.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2V4U0
    Conserved Domains (1) summary
    pfam00233
    Location:405 → 646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  5. NM_001306543.3 → NP_001293472.1  Phosphodiesterase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293472.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FCW6
    Conserved Domains (1) summary
    pfam00233
    Location:356 → 597
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. NM_063199.7 → NP_495600.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
    Conserved Domains (1) summary
    pfam00233
    Location:358 → 599
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  7. NM_001393120.1 → NP_001379886.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    pfam00233
    Location:331 → 572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:82 → 198
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  8. NM_182147.5 → NP_871947.1  putative 3',5'-cyclic-AMP phosphodiesterase pde-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871947.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22000
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22000.2

Gene LinkOut

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