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Mllt10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [ Mus musculus (house mouse) ]

Gene ID: 17354, updated on 2-Nov-2024

Summary

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Official Symbol
Mllt10provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10provided by MGI
Primary source
MGI:MGI:1329038
See related
Ensembl:ENSMUSG00000026743 AllianceGenome:MGI:1329038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af10; mKIAA4140; B130021D15Rik; D630001B22Rik
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mllt10 in Genome Data Viewer
Location:
2 A3; 2 12.84 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18059971..18217201)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18055160..18212390)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930004D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:17949221-17949330 Neighboring gene STARR-positive B cell enhancer ABC_E11122 Neighboring gene predicted gene, 33085 Neighboring gene predicted gene, 17762 Neighboring gene SKI/DACH domain containing 1 Neighboring gene microRNA 7655 Neighboring gene STARR-seq mESC enhancer starr_03800 Neighboring gene predicted gene, 25147 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_03801 Neighboring gene STARR-seq mESC enhancer starr_03802 Neighboring gene STARR-positive B cell enhancer ABC_E11123 Neighboring gene STARR-seq mESC enhancer starr_03803 Neighboring gene STARR-seq mESC enhancer starr_03805 Neighboring gene STARR-seq mESC enhancer starr_03806 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:18424168-18424351 Neighboring gene STARR-seq mESC enhancer starr_03808 Neighboring gene STARR-seq mESC enhancer starr_03809 Neighboring gene STARR-seq mESC enhancer starr_03810 Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression pattern and cellular distribution of the murine homologue of AF10. Linder B, et al. Biochim Biophys Acta, 1998 Dec 22. PMID 9878787
  2. The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice. Deshpande AJ, et al. Leukemia, 2011 Nov. PMID 21681188
  3. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations. Klein BJ, et al. Nat Commun, 2021 Jul 5. PMID 34226546, Free PMC Article
  4. MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer. Jing X, et al. Scand J Gastroenterol, 2018 Aug. PMID 30102091
  5. Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia. Suzuki M, et al. Cancer Sci, 2014 Mar. PMID 24397609, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
    Title: The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
  2. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
    Title: The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
  3. Together these data are the first to demonstrate that Af10-dependent H3K79me is essential for development of nasal processes and adjacent tissues, and consequent midfacial formation.
    Title: Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development.
  4. In lung metastasis sites, the knockdown of MLLT10 in SW620 cells significantly inhibited Vimentin expression, whereas the E-Cadherin was increased. These results indicate that MLLT10 regulates the metastasis of CRC cells via EMT.
    Title: MLLT10 promotes tumor migration, invasion, and metastasis in human colorectal cancer.
  5. Results provide evidence that transformation driven by MLL fusions as well as the recurrent AML-associated NUP98-NSD1 fusion oncogene is critically dependent on the ability of AF10 to stimulate DOT1L activity.
    Title: AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
  6. During leukemogenesis, CALM-AF10 plays critical roles in the cytoplasm.
    Title: Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia.
  7. In leukemia cells, full-length CALM-AF10 localized to the nucleus with no consistent effect on growth factor endocyctosis, and suppressed histone H3 lysine 79 methylation regardless of the presence of clathrin
    Title: The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.
  8. further suggest that future approaches to antagonize CALM-AF10-induced transformation should incorporate strategies, which aim at blocking these key domains
    Title: The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.
  9. conclude that Mllt10/Af10-Dot1l are essential, largely dedicated activators of Wnt-dependent transcription, critical for maintenance of intestinal proliferation and homeostasis
    Title: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4140

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein AF-10
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252560.1 → NP_001239489.1  protein AF-10 isoform 1

    See identical proteins and their annotated locations for NP_001239489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL928557, AL928589
    Consensus CDS
    CCDS15708.1
    UniProtKB/Swiss-Prot
    O54826, Q6NS43
    UniProtKB/TrEMBL
    Q5DTL6
    Related
    ENSMUSP00000110328.3, ENSMUST00000114680.9
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  2. NM_001252561.1 → NP_001239490.1  protein AF-10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL928557, AL928589
    Consensus CDS
    CCDS57155.1
    UniProtKB/TrEMBL
    A2AS70, Q5DTL6
    Related
    ENSMUSP00000110319.2, ENSMUST00000114671.8
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  3. NM_010804.4 → NP_034934.2  protein AF-10 isoform 1

    See identical proteins and their annotated locations for NP_034934.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC070475, BY608946, CN534499, CN537566
    Consensus CDS
    CCDS15708.1
    UniProtKB/Swiss-Prot
    O54826, Q6NS43
    UniProtKB/TrEMBL
    Q5DTL6
    Related
    ENSMUSP00000028076.9, ENSMUST00000028076.15
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

RNA

  1. NR_045538.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK045042, AK052207, AL928557, AL928589, BC070475

  2. NR_045539.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL928557, AL928589

  3. NR_149308.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK045042, AK158426, AL928557

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    18059971..18217201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248197.2 → XP_030104057.1  protein AF-10 isoform X13

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:598 → 661
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 87
    PHD_SF; PHD finger superfamily

  2. XM_030248200.2 → XP_030104060.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  3. XM_030248116.2 → XP_030103976.1  protein AF-10 isoform X1

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  4. XM_006497389.4 → XP_006497452.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  5. XM_006497390.4 → XP_006497453.1  protein AF-10 isoform X16

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (1) summary
    cl22851
    Location:1 → 52
    PHD_SF; PHD finger superfamily

  6. XM_006497373.5 → XP_006497436.2  protein AF-10 isoform X1

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  7. XM_036159019.1 → XP_036014912.1  protein AF-10 isoform X2

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:706 → 769
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  8. XM_006497375.5 → XP_006497438.2  protein AF-10 isoform X3

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 203
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  9. XM_030248112.2 → XP_030103972.1  protein AF-10 isoform X6

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:81 → 151
    PHD_SF; PHD finger superfamily

  10. XM_006497382.5 → XP_006497445.2  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  11. XM_006497377.5 → XP_006497440.2  protein AF-10 isoform X4

    UniProtKB/Swiss-Prot
    O54826, Q6NS43
    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  12. XM_017316073.3 → XP_017171562.1  protein AF-10 isoform X7

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (3) summary
    sd00025
    Location:66 → 85
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 203
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  13. XM_036159032.1 → XP_036014925.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  14. XM_030248136.2 → XP_030103996.1  protein AF-10 isoform X8

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  15. XM_030248168.2 → XP_030104028.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  16. XM_036159035.1 → XP_036014928.1  protein AF-10 isoform X11

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 125
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:607 → 670
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  17. XM_030248178.2 → XP_030104038.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  18. XM_030248113.2 → XP_030103973.1  protein AF-10 isoform X1

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  19. XM_030248120.2 → XP_030103980.1  protein AF-10 isoform X3

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 203
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  20. XM_036159034.1 → XP_036014927.1  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd20901
    Location:630 → 693
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:81 → 148
    PHD_SF; PHD finger superfamily

  21. XM_036159027.1 → XP_036014920.1  protein AF-10 isoform X8

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  22. XM_030248154.2 → XP_030104014.1  protein AF-10 isoform X8

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  23. XM_030248187.2 → XP_030104047.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  24. XM_036159033.1 → XP_036014926.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  25. XM_030248193.2 → XP_030104053.1  protein AF-10 isoform X11

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 125
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:607 → 670
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  26. XM_030248114.2 → XP_030103974.1  protein AF-10 isoform X1

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  27. XM_030248127.2 → XP_030103987.1  protein AF-10 isoform X3

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 203
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

  28. XM_036159031.1 → XP_036014924.1  protein AF-10 isoform X6

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:81 → 151
    PHD_SF; PHD finger superfamily

  29. XM_030248156.2 → XP_030104016.1  protein AF-10 isoform X8

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  30. XM_036159037.1 → XP_036014930.1  protein AF-10 isoform X13

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:598 → 661
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 87
    PHD_SF; PHD finger superfamily

  31. XM_036159048.1 → XP_036014941.1  protein AF-10 isoform X17

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:552 → 615
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 70
    PHD_SF; PHD finger superfamily

  32. XM_030248195.2 → XP_030104055.1  protein AF-10 isoform X13

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:598 → 661
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 87
    PHD_SF; PHD finger superfamily

  33. XM_036159041.1 → XP_036014934.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  34. XM_036159038.1 → XP_036014931.1  protein AF-10 isoform X14

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:584 → 647
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 73
    PHD_SF; PHD finger superfamily

  35. XM_036159040.1 → XP_036014933.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  36. XM_036159044.1 → XP_036014937.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  37. XM_017316080.3 → XP_017171569.1  protein AF-10 isoform X16

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (1) summary
    cl22851
    Location:1 → 52
    PHD_SF; PHD finger superfamily

  38. XM_036159039.1 → XP_036014932.1  protein AF-10 isoform X14

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:584 → 647
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 73
    PHD_SF; PHD finger superfamily

  39. XM_036159049.1 → XP_036014942.1  protein AF-10 isoform X17

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:552 → 615
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 70
    PHD_SF; PHD finger superfamily

  40. XM_030248196.2 → XP_030104056.1  protein AF-10 isoform X13

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:598 → 661
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 87
    PHD_SF; PHD finger superfamily

  41. XM_036159042.1 → XP_036014935.1  protein AF-10 isoform X15

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (2) summary
    cd20901
    Location:566 → 629
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 84
    PHD_SF; PHD finger superfamily

  42. XM_030248194.2 → XP_030104054.1  protein AF-10 isoform X12

    UniProtKB/TrEMBL
    A2AS70, Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  43. XM_036159036.1 → XP_036014929.1  protein AF-10 isoform X12

    UniProtKB/TrEMBL
    A2AS70, Q5DTL6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  44. XM_030248210.2 → XP_030104070.1  protein AF-10 isoform X18

    UniProtKB/TrEMBL
    Q5DTL6
    Conserved Domains (1) summary
    cl22851
    Location:3 → 73
    PHD_SF; PHD finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54826.2 GenPept UniProtKB/Swiss-Prot:O54826

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