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cox-4 Cytochrome c oxidase subunit 4 [ Caenorhabditis elegans ]

Gene ID: 173237, updated on 2-Nov-2024

Summary

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Official Symbol
cox-4
Official Full Name
Cytochrome c oxidase subunit 4
Primary source
WormBase:WBGene00012354
Locus tag
CELE_W09C5.8
See related
AllianceGenome:WB:WBGene00012354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cox-4 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (13658171..13659128, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL31 Neighboring gene Inositol phosphatase domain-containing protein;SAC domain-containing protein Neighboring gene pseudo Neighboring gene Leucine Rich repeat-containing domain protein Neighboring gene INTegrator complex Subunit homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dichloroacetate and thiamine improve survival and mitochondrial stress in a C. elegans model of dihydrolipoamide dehydrogenase deficiency. Broxton CN, et al. JCI Insight, 2022 Oct 24. PMID 36278487, Free PMC Article
  2. Complex I function is defective in complex IV-deficient Caenorhabditis elegans. Suthammarak W, et al. J Biol Chem, 2009 Mar 6. PMID 19074434, Free PMC Article
  3. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. Rea SL, et al. PLoS Biol, 2007 Oct 2. PMID 17914900, Free PMC Article
  4. Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Ventura N, et al. Biotechnol J, 2007 May. PMID 17443764
  5. Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains. Samuelson AV, et al. Cold Spring Harb Symp Quant Biol, 2007. PMID 18419309

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cytochrome c oxidase subunit 4
NP_493394.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13658171..13659128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060993.5 → NP_493394.1  Cytochrome c oxidase subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_493394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U329
    Conserved Domains (1) summary
    pfam02936
    Location:45 → 175
    COX4; Cytochrome c oxidase subunit IV
Nucleotide Protein
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