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gale-1 UDP-glucose 4-epimerase [ Caenorhabditis elegans ]

Gene ID: 173171, updated on 2-Nov-2024

Summary

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Official Symbol
gale-1
Official Full Name
UDP-glucose 4-epimerase
Primary source
WormBase:WBGene00008132
Locus tag
CELE_C47B2.6
See related
AllianceGenome:WB:WBGene00008132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables UDP-N-acetylglucosamine 4-epimerase activity and UDP-glucose 4-epimerase activity. Involved in several processes, including gonad morphogenesis; negative regulation of endoplasmic reticulum unfolded protein response; and positive regulation of vulval development. Predicted to be active in cytosol. Is expressed in head; hypodermis; intestine; nervous system; and reproductive system. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency and thrombocytopenia. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gale-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (12970241..12978787)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tubulin alpha-2 chain Neighboring gene Proteasome subunit beta Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene Peroxisomal biogenesis factor 11 Neighboring gene Tr-type G domain-containing protein Neighboring gene RNA-binding S4 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the Caenorhabditis elegans UDP-galactopyranose mutase homolog glf-1 reveals an essential role for galactofuranose metabolism in nematode surface coat synthesis. Novelli JF, et al. Dev Biol, 2009 Nov 15. PMID 19751718
  2. Developmental defects in a Caenorhabditis elegans model for type III galactosemia. Brokate-Llanos AM, et al. Genetics, 2014 Dec. PMID 25298520, Free PMC Article
  3. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
  4. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
  5. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylglucosamine 4-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in cuticle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gonad morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of distal tip cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UDP-glucose 4-epimerase
NP_001021051.1
  • Confirmed by transcript evidence
NP_001021052.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12970241..12978787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025880.3 → NP_001021051.1  UDP-glucose 4-epimerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021051.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q564Q1
    Conserved Domains (2) summary
    cd05247
    Location:2 → 339
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
    TIGR01179
    Location:3 → 341
    galE; UDP-glucose-4-epimerase GalE

  2. NM_001025881.7 → NP_001021052.1  UDP-glucose 4-epimerase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021052.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62107, Q564Q1
    Conserved Domains (1) summary
    cd05247
    Location:2 → 341
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q564Q1.1

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