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unc-101 AP-1 complex subunit mu-1-I;MHD domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 173121, updated on 2-Nov-2024

Summary

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Official Symbol
unc-101
Official Full Name
AP-1 complex subunit mu-1-I;MHD domain-containing protein
Primary source
WormBase:WBGene00006829
Locus tag
CELE_K11D2.3
See related
AllianceGenome:WB:WBGene00006829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable clathrin adaptor activity. Involved in several processes, including apical protein localization; nematode larval development; and receptor localization to non-motile cilium. Predicted to be located in Golgi apparatus; clathrin-coated vesicle membrane; and dendrite. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including germ line; head; nervous system; and tail. Orthologous to several human genes including AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-101 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (12508299..12513420)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene RCC1 domain-containing protein 1 Neighboring gene Acid ceramidase subunit beta Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Dwyer ND, et al. Neuron, 2001 Aug 2. PMID 11502258
  2. Trafficking prerogatives of olfactory receptors. McClintock TS, et al. Neuroreport, 2003 Aug 26. PMID 14502073
  3. A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. Zhou X, et al. FEBS Lett, 2016 Jan. PMID 26762178
  4. The AP-1 clathrin adaptor facilitates cilium formation and functions with RAB-8 in C. elegans ciliary membrane transport. Kaplan OI, et al. J Cell Sci, 2010 Nov 15. PMID 20980383, Free PMC Article
  5. LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α. Nadiminti SSP, et al. PLoS Genet, 2024 May. PMID 38722918, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest UNC-101/AP-1 mu1 subunit exhibits a novel bipartite sorting signal within KVS-4/Kv2.1 consisting of C-terminal EQMIL and N-terminal WNIIE motifs; such sorting signals appear to account for somatodendritic distribution of KVS-4/Kv2.1.
    Title: A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.
  2. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 basolateral localization and signaling during C. elegans vulva induction.
    Title: An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apical protein localization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor localization to non-motile cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vulval development NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AP-1 complex subunit mu-1-I;MHD domain-containing protein
NP_001040675.1
  • Confirmed by transcript evidence
NP_001040676.1
  • Partially confirmed by transcript evidence
NP_001251914.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12508299..12513420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047210.4 → NP_001040675.1  AP-1 complex subunit mu-1-I [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040675.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02282, P35602, Q1ZXR6
    Conserved Domains (2) summary
    cl02092
    Location:5 → 126
    Clat_adaptor_s; Clathrin adaptor complex small chain
    cd09258
    Location:152 → 421
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

  2. NM_001264985.3 → NP_001251914.1  MHD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D7SFR1
    Conserved Domains (1) summary
    cd09258
    Location:3 → 272
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

  3. NM_001047211.3 → NP_001040676.1  AP-1 complex subunit mu-1-I [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040676.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35602
    Conserved Domains (1) summary
    cl10970
    Location:1 → 57
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35602.2

Gene LinkOut

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