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exo-3 DNA-(apurinic or apyrimidinic site) endonuclease;exodeoxyribonuclease III [ Caenorhabditis elegans ]

Gene ID: 173069, updated on 2-Nov-2024

Summary

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Official Symbol
exo-3
Official Full Name
DNA-(apurinic or apyrimidinic site) endonuclease;exodeoxyribonuclease III
Primary source
WormBase:WBGene00001372
Locus tag
CELE_R09B3.1
See related
AllianceGenome:WB:WBGene00001372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity and phosphoric diester hydrolase activity. Involved in base-excision repair; embryo development; and nematode larval development. Predicted to be active in nucleus. Is expressed in hermaphrodite gonad and male gonad. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exo-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (11907571..11909251, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene RRM domain-containing protein Neighboring gene RRM domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA. Shatilla A, et al. Biochemistry, 2005 Sep 27. PMID 16171399
  2. Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. Yang X, et al. DNA Repair (Amst), 2012 Oct 1. PMID 22819077
  3. Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation. Shatilla A, et al. DNA Repair (Amst), 2005 Jun 8. PMID 15907773
  4. The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans. Elsakrmy N, et al. Front Cell Dev Biol, 2020. PMID 33344454, Free PMC Article
  5. UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Papaluca A, et al. Sci Rep, 2018 May 1. PMID 29717169, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans
    Title: AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans.
  2. This study demonstrated differential roles of EXO-3 in somatic cells and germ cells.
    Title: Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: differential roles in somatic cells and germ cells.
  3. Base excision repair endonucleases APN-1 and EXO-3 function in the same pathway as DNA mismatch repair, to elicit DNA-directed toxicity in response to 5-fluorouracil.
    Title: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.
  4. Glu68 may play a role in coordinating Mg2+ binding for the enzyme catalytic mechanism.
    Title: Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA.
  5. Exo-3 expresses apurinic/apyrimidinic endonuclease in a Saccharomyces cerevisiae mutant.
    Title: Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-(apurinic or apyrimidinic site) endonuclease;exodeoxyribonuclease III
NP_001021584.1
  • Confirmed by transcript evidence
NP_001021585.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11907571..11909251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026413.7 → NP_001021584.1  exodeoxyribonuclease III [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBR7
    Conserved Domains (1) summary
    cd09087
    Location:35 → 286
    Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

  2. NM_001026414.5 → NP_001021585.1  DNA-(apurinic or apyrimidinic site) endonuclease [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021585.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q564V5
    Conserved Domains (1) summary
    cl00490
    Location:35 → 179
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version

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