hmr-1 Cadherin-related hmr-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: hmr-1
Official Full Name: Cadherin-related hmr-1
Primary source: WormBase:WBGene00001980
Locus tag: CELE_W02B9.1
See related: AllianceGenome:WB:WBGene00001980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-catenin binding activity and delta-catenin binding activity. Involved in cytoskeleton organization; embryo development; and gastrulation. Located in adherens junction. Is spanning component of plasma membrane. Part of catenin complex. Is expressed in several structures, including distal tip cell; hypodermis; motor neurons; nerve ring; and neuroblasts. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See hmr-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 31

Sequence:: Chromosome: I; NC_003279.8 (11075758..11134667, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
Title: Persistent cell contacts enable E-cadherin/HMR-1- and PAR-3-based symmetry breaking within a developing C. elegans epithelium.
HMP-1 bound filamentous actin with an affinity in the single micromolar range, even when complexed with the beta-catenin homolog HMP-2 or when present in a complex of HMP-2 and the cadherin homolog HMR-1, indicating that HMP-1 binding to F-actin is not allosterically regulated by the HMP-2.HMR-1 complex.
Title: Structural and functional characterization of Caenorhabditis elegans α-catenin reveals constitutive binding to β-catenin and F-actin.
sax-7 and hmr-1 function redundantly in blastomere compaction and non-muscle myosin accumulation during C. elegans gastrulation.
Title: SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS1-192 (e-PCR)
- UniSTS:241683

Y52B11B.2 (e-PCR)
- UniSTS:312876

Y52B11B.1 (e-PCR)
- UniSTS:316215

ZK39.1 (e-PCR)
- UniSTS:312911

W02B9.1 (e-PCR)
- UniSTS:318574

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables delta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in apical constriction involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in distal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Cadherin-related hmr-1

NP_001021650.1

Confirmed by transcript evidence

NP_001251561.1

Confirmed by transcript evidence

NP_001368105.1

Confirmed by transcript evidence

NP_001379266.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

11075758..11134667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026479.4 → NP_001021650.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021650.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B2MZC5, H2FLJ9, H2FLK0, O44327, Q967F4

Conserved Domains (5) summary

cd11304
Location:647 → 742

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:2250 → 2283

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:2286 → 2459

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:2812 → 2919

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:2533 → 2679

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001392947.1 → NP_001379266.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (5) summary

cd11304
Location:127 → 217

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:600 → 632

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:635 → 808

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:1161 → 1268

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:882 → 1028

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001264632.3 → NP_001251561.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001251561.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q967F4

Conserved Domains (5) summary

cd11304
Location:26 → 129

Cadherin_repeat; Cadherin tandem repeat domain

cd00054
Location:395 → 427

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:430 → 603

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:956 → 1063

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:677 → 823

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001381216.1 → NP_001368105.1 Cadherin-related hmr-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

cd00054
Location:265 → 297

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:300 → 473

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01049
Location:826 → 933

Cadherin_C; Cadherin cytoplasmic region

cl22861
Location:547 → 693

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...