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nra-2 Nicalin [ Caenorhabditis elegans ]

Gene ID: 172803, updated on 9-Dec-2024

Summary

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Official Symbol
nra-2
Official Full Name
Nicalin
Primary source
WormBase:WBGene00011488
Locus tag
CELE_T05F1.1
See related
AllianceGenome:WB:WBGene00011488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in protein-containing complex assembly and regulation of protein targeting to membrane. Located in endoplasmic reticulum. Is expressed in body wall musculature; egg-laying apparatus; excretory canal; neurons; and pharyngeal muscle cell. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nra-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9620227..9622377)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative histone-binding protein rba-1 Neighboring gene putative histone-binding protein lin-53 Neighboring gene F-box associated domain-containing protein Neighboring gene Small ribosomal subunit protein eS19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels. Kamat S, et al. J Biol Chem, 2014 Apr 25. PMID 24567339, Free PMC Article
  2. An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse. Almedom RB, et al. EMBO J, 2009 Sep 2. PMID 19609303, Free PMC Article
  3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nicalin
NP_001122514.1
  • Confirmed by transcript evidence
NP_492553.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9620227..9622377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129042.4 → NP_001122514.1  Nicalin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5JYX8, O18033
    Conserved Domains (1) summary
    cd03882
    Location:121 → 430
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

  2. NM_060152.5 → NP_492553.1  Nicalin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18033
    Conserved Domains (1) summary
    cd03882
    Location:124 → 424
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5JYX8.1

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