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tlf-1 TATA box-binding protein-like 1 [ Caenorhabditis elegans ]

Gene ID: 172676, updated on 2-Nov-2024

Summary

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Official Symbol
tlf-1
Official Full Name
TATA box-binding protein-like 1
Primary source
WormBase:WBGene00006577
Locus tag
CELE_F39H11.2
See related
AllianceGenome:WB:WBGene00006577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable general transcription initiation factor activity. Involved in embryo development; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including germ line. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tlf-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (8697504..8701973, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MBD domain-containing protein;Pre-mRNA-splicing factor SLU7;Pre-mRNA-splicing factor SYF2 Neighboring gene putative ATP synthase subunit g 1, mitochondrial Neighboring gene Proteasome subunit beta Neighboring gene Craniofacial development protein 1 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene Collagen alpha-1(XVIII) chain;Endostatin domain-containing protein;Fibronectin type-III domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene silencing in Caenorhabditis elegans by transitive RNA interference. Alder MN, et al. RNA, 2003 Jan. PMID 12554873, Free PMC Article
  2. TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans. Dantonel JC, et al. Mol Cell, 2000 Sep. PMID 11030350
  3. The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis. Kaltenbach L, et al. Mol Cell, 2000 Sep. PMID 11030349
  4. Analysis of the role of Caenorhabditis elegans GC-AG introns in regulated splicing. Farrer T, et al. Nucleic Acids Res, 2002 Aug 1. PMID 12140320, Free PMC Article
  5. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. Kniazeva M, et al. PLoS Biol, 2004 Sep. PMID 15340492, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. during C. elegans embryogenesis TAF-1 and TFIID have broad roles in transcription and development
    Title: An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TATA box-binding protein-like 1
NP_001122474.1
  • Confirmed by transcript evidence
NP_492356.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8697504..8701973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059955.7 → NP_492356.1  TATA box-binding protein-like 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC52
    Conserved Domains (2) summary
    PLN00062
    Location:265 → 441
    PLN00062; TATA-box-binding protein; Provisional
    cd04517
    Location:263 → 439
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

  2. NM_001129002.4 → NP_001122474.1  TATA box-binding protein-like 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B2D6P4, G5EC52, Q9XZQ7
    Conserved Domains (2) summary
    cd04517
    Location:266 → 442
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
    cl41729
    Location:183 → 217
    KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2D6P4.1

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