ego-1 RNA-directed RNA polymerase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ego-1
Official Full Name: RNA-directed RNA polymerase
Primary source: WormBase:WBGene00001214
Locus tag: CELE_F26A3.3
See related: AllianceGenome:WB:WBGene00001214
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA-dependent RNA polymerase activity. Involved in several processes, including P granule assembly; nuclear pore localization; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in P granule; condensed nuclear chromosome; and metaphase plate. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ego-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 15

Sequence:: Chromosome: I; NC_003279.8 (7650341..7656338, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we demonstrate that EGO-1 can compensate for the lack of RRF-1 when dsRNA from neurons is used to silence genes in intestinal cells.
Title: Gene silencing by double-stranded RNA from C. elegans neurons reveals functional mosaicism of RNA interference.
EGO-1, a C. elegans RdRP, modulates gene expression via production of mRNA-templated short antisense RNAs.
Title: EGO-1, a C. elegans RdRP, modulates gene expression via production of mRNA-templated short antisense RNAs.
EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules.
Title: EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis elegans.
EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna leading to transcriptional silencing during C. elegans meiosis.
Title: EGO-1, a putative RNA-dependent RNA polymerase, is required for heterochromatin assembly on unpaired dna during C. elegans meiosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26A3.3 (e-PCR)
- UniSTS:307540

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-dependent RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA-dependent RNA polymerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in P granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear pore localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in metaphase plate	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear RNA-directed RNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-directed RNA polymerase

NP_492132.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7650341..7656338 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059731.6 → NP_492132.1 RNA-directed RNA polymerase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492132.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBQ3

Conserved Domains (1) summary

pfam05183
Location:506 → 1062

RdRP; RNA dependent RNA polymerase