ahcy-1 Adenosylhomocysteinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ahcy-1
Official Full Name: Adenosylhomocysteinase
Primary source: WormBase:WBGene00019322
Locus tag: CELE_K02F2.2
See related: AllianceGenome:WB:WBGene00019322
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable adenosylhomocysteinase activity. Predicted to be involved in S-adenosylhomocysteine catabolic process and S-adenosylmethionine cycle. Predicted to be active in cytosol. Is expressed in head; intestine; and pharynx. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ahcy-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (6836469..6838140)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K02F2.2 (e-PCR)
- UniSTS:311371

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables adenosylhomocysteinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylhomocysteinase activity	IEA Inferred from Electronic Annotation more info
enables adenosylhomocysteinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in S-adenosylmethionine cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Adenosylhomocysteinase

NP_491955.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6836469..6838140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059554.9 → NP_491955.1 Adenosylhomocysteinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491955.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27604

Conserved Domains (2) summary

PRK05476
Location:1 → 431

PRK05476; S-adenosyl-L-homocysteine hydrolase; Provisional

pfam05221
Location:8 → 436

AdoHcyase; S-adenosyl-L-homocysteine hydrolase