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aprt-1 Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase [ Caenorhabditis elegans ]

Gene ID: 172232, updated on 18-Sep-2024

Summary

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Official Symbol
aprt-1
Official Full Name
Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase
Primary source
WormBase:WBGene00020557
Locus tag
CELE_T19B4.3
See related
AllianceGenome:WB:WBGene00020557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See aprt-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (5678638..5679862)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Mitochondrial import inner membrane translocase subunit TIM14 Neighboring gene Netrin receptor unc-40 Neighboring gene RanBP2-type domain-containing protein Neighboring gene putative peptidylglycine alpha-hydroxylating monooxygenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in adenine salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenine salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase
NP_001407543.1
  • Confirmed by transcript evidence
NP_491663.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5678638..5679862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059262.10 → NP_491663.1  Adenine phosphoribosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491663.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91455
    Conserved Domains (1) summary
    PRK02304
    Location:12 → 183
    PRK02304; adenine phosphoribosyltransferase; Provisional

  2. NM_001420561.1 → NP_001407543.1  adenine phosphoribosyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A9J5HXB2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91455.1

Gene LinkOut

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