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aap-1 SH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172141, updated on 2-Nov-2024

Summary

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Official Symbol
aap-1
Official Full Name
SH2 domain-containing protein
Primary source
WormBase:WBGene00000001
Locus tag
CELE_Y110A7A.10
See related
AllianceGenome:WB:WBGene00000001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in dauer larval development; determination of adult lifespan; and insulin receptor signaling pathway. Part of phosphatidylinositol 3-kinase complex. Is expressed in anchor cell; intestine; and neurons. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; carcinoma (multiple); endometrial cancer (multiple); and immunodeficiency 36. Orthologous to several human genes including PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aap-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (5107843..5110183)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome subunit alpha type-4 Neighboring gene Vesicle transport protein USE1 Neighboring gene MARVEL domain-containing protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Elongator complex protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus. Li FC, et al. Parasit Vectors, 2014 Nov 12. PMID 25388625, Free PMC Article
  2. Thermotolerance of tax-2 Is Uncoupled From Life Span Extension and Influenced by Temperature During Development in C. elegans. Hwang HY, et al. Front Genet, 2020. PMID 33133151, Free PMC Article
  3. Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. Wolkow CA, et al. J Biol Chem, 2002 Dec 20. PMID 12393910
  4. Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Muñoz MJ, et al. Genetics, 2003 Jan. PMID 12586705, Free PMC Article
  5. Longevity and heat stress regulation in Caenorhabditis elegans. Muñoz MJ. Mech Ageing Dev, 2003 Jan. PMID 12618005

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AAP-1 potentiates the C. elegans signal transduction pathway, but is not required; it plays a role in nematode development
    Title: Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2 domain-containing protein
NP_491522.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5107843..5110183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059121.9 → NP_491522.1  SH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491522.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDP9
    Conserved Domains (1) summary
    cl15255
    Location:12 → 121
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
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