U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Matr3 matrin 3 [ Mus musculus (house mouse) ]

Gene ID: 17184, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Matr3provided by MGI
Official Full Name
matrin 3provided by MGI
Primary source
MGI:MGI:1298379
See related
Ensembl:ENSMUSG00000037236 AllianceGenome:MGI:1298379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0723; 1110061A14Rik; 2810017I02Rik; D030046F20Rik
Summary
Predicted to enable identical protein binding activity and miRNA binding activity. Acts upstream of or within blastocyst formation; heart valve development; and ventricular septum development. Located in nucleus. Is expressed in several structures, including blood vessel layer; branchial arch; heart; lung; and telencephalon. Used to study amyotrophic lateral sclerosis type 21. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 21. Orthologous to human MATR3 (matrin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 68.8), CNS E18 (RPKM 62.6) and 19 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Matr3 in Genome Data Viewer
Location:
18 B2; 18 19.14 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35686462..35724526)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35562158..35592045)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene predicted gene, 41692 Neighboring gene microRNA 1949 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E9973 Neighboring gene STARR-positive B cell enhancer ABC_E5651 Neighboring gene polyadenylate-binding protein-interacting protein 2 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor. Cheng X, et al. Mol Metab, 2024 Aug. PMID 38936659, Free PMC Article
  2. Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. Rayaprolu S, et al. J Comp Neurol, 2016 Oct 1. PMID 26878116, Free PMC Article
  3. MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS. van Bruggen R, et al. Biochem Biophys Res Commun, 2021 Sep 3. PMID 34182213
  4. MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS. Dominick M, et al. Biochem Biophys Res Commun, 2023 Feb 19. PMID 36689813, Free PMC Article
  5. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Cha HJ, et al. Nat Commun, 2021 Oct 29. PMID 34716321, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
    Title: Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor.
  2. MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
    Title: MATR3 P154S knock-in mice do not exhibit motor, muscle or neuropathologic features of ALS.
  3. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
    Title: Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture.
  4. MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
    Title: MATR3 F115C knock-in mice do not exhibit motor defects or neuropathological features of ALS.
  5. Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
    Title: Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS.
  6. proteomic approach revealed that Matrin-3 phosphorylation was essential for FGF2-dependent maintenance of NSCs in vitro and in vivo.
    Title: Matrin-3 is essential for fibroblast growth factor 2-dependent maintenance of neural stem cells.
  7. Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 together with PABPN1 is required for normal paraspeckle function.
    Title: Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing.
  8. Matrin 3 declines significantly in the central nervous system through early development and young adulthood before stabilizing.
    Title: Heterogeneity of Matrin 3 in the developing and aging murine central nervous system.
  9. Matr3(Gt-ex13) gene trap insertion disturb the polyadenylation of MATR3 transcripts and alter Matrin 3 protein expression.
    Title: MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
  10. Matrin 3 interacts specifically with the heat shock proteins glucose-regulated protein 78, GRP75 and glutathione S-transferase pi isoform 2.
    Title: Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase π isoform 2 (GSTπ2) in thymoma cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart valve development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
matrin-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399983.1 → NP_001386912.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18

  2. NM_001399984.1 → NP_001386913.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18
    Related
    ENSMUSP00000158074.2, ENSMUST00000235199.2

  3. NM_001399985.1 → NP_001386914.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18

  4. NM_001399986.1 → NP_001386915.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18

  5. NM_001399988.1 → NP_001386917.1  matrin-3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC121821

  6. NM_001399989.1 → NP_001386918.1  matrin-3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/TrEMBL
    A0A494BAD4
    Related
    ENSMUSP00000158036.2, ENSMUST00000237365.2

  7. NM_001399990.1 → NP_001386919.1  matrin-3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/TrEMBL
    A0A494BAZ7
    Related
    ENSMUSP00000157641.2, ENSMUST00000237061.2

  8. NM_001399991.1 → NP_001386920.1  matrin-3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/TrEMBL
    A0A494BAZ7
    Related
    ENSMUSP00000158418.2, ENSMUST00000235960.2

  9. NM_001399992.1 → NP_001386921.1  matrin-3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/TrEMBL
    A0A494BAZ7
    Related
    ENSMUSP00000158302.2, ENSMUST00000236507.2

  10. NM_001399993.1 → NP_001386922.1  matrin-3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/TrEMBL
    A0A494BAZ7

  11. NM_001414500.1 → NP_001401429.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18

  12. NM_001414501.1 → NP_001401430.1  matrin-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC121821
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q5BL18

  13. NM_001414502.1 → NP_001401431.1  matrin-3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC121821

  14. NM_010771.7 → NP_034901.2  matrin-3 isoform a

    See identical proteins and their annotated locations for NP_034901.2

    Status: VALIDATED

    Source sequence(s)
    AC121821
    Consensus CDS
    CCDS29142.1
    UniProtKB/Swiss-Prot
    Q8K310
    UniProtKB/TrEMBL
    Q3TTX0, Q4FJT0, Q5BL18
    Related
    ENSMUSP00000125761.2, ENSMUST00000166793.10
    Conserved Domains (4) summary
    smart00451
    Location:797 → 832
    ZnF_U1; U1-like zinc finger
    COG5271
    Location:567 → 777
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cd12714
    Location:398 → 473
    RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
    cd12715
    Location:496 → 575
    RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35686462..35724526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K310.1 GenPept UniProtKB/Swiss-Prot:Q8K310

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools