U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

eif-2gamma protein-synthesizing GTPase [ Caenorhabditis elegans ]

Gene ID: 171792, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
eif-2gamma
Official Full Name
protein-synthesizing GTPase
Primary source
WormBase:WBGene00021466
Locus tag
CELE_Y39G10AR.8
See related
AllianceGenome:WB:WBGene00021466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex. Predicted to be part of eukaryotic translation initiation factor 2 complex. Is expressed in several structures, including enteric muscle; nervous system; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to human EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma) and EIF2S3B (eukaryotic translation initiation factor 2 subunit gamma B). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See eif-2gamma in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (2313271..2315992)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 5-methylcytosine rRNA methyltransferase nsun-4 Neighboring gene Tubulin-specific chaperone A Neighboring gene ncRNA Neighboring gene PEHE domain-containing protein Neighboring gene DNA replication licensing factor mcm-4 Neighboring gene BLOC-1-related complex subunit 7;Biogenesis of lysosome-related organelles complex 1 subunit 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article
  2. Cell size and fat content of dietary-restricted Caenorhabditis elegans are regulated by ATX-2, an mTOR repressor. Bar DZ, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27457958, Free PMC Article
  3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  4. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
  5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-synthesizing GTPase
NP_490960.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2313271..2315992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058559.9 → NP_490960.1  protein-synthesizing GTPase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XR0
    Conserved Domains (1) summary
    PTZ00327
    Location:14 → 465
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.