egl-30 Guanine nucleotide-binding protein subunit alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-30
Official Full Name: Guanine nucleotide-binding protein subunit alpha
Primary source: WormBase:WBGene00001196
Locus tag: CELE_M01D7.7
See related: AllianceGenome:WB:WBGene00001196
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including cellular response to dopamine; positive regulation of protein localization; and regulation of secretion. Located in axon; cell cortex; and neuronal cell body. Is expressed widely. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; autosomal dominant hypocalcemia 2; congestive heart failure; familial hypocalciuric hypercalcemia 2; and familial multiple nevi flammei. Orthologous to several human genes including GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-30 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (1835661..1841965)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGL-30 facilitates training-dependent induction of tph-1 by functional regulation of olfactory sensory neurons, which underscores the importance of sensory experience
Title: A neuronal signaling pathway of CaMKII and Gqα regulates experience-dependent transcription of tph-1.
This paper provides evidence that while goa-1 and egl-30 are important for normal daf-7 expression, mutations in these genes are not sufficient to disrupt dauer formation.
Title: Gαo and Gαq regulate the expression of daf-7, a TGFβ-like gene, in Caenorhabditis elegans.
a conserved Galphaq pathway cooperates with cell specific factors in the nervous and immune systems of Caenorhabditis elegans to produce appropriate responses to pathogen
Title: Behavioral and immune responses to infection require Gαq- RhoA signaling in C. elegans.
A gain-of-function mutation in egl-30 Gqalpha was epistatic to gpc-1, suggesting the possibility that gpc-1 Ggamma may act upstream of egl-30 Gqalpha.
Title: GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans.
Serotonin signaling is regulated by modulating serotonin biosynthesis and Galphao and Galphaq act in the same neurons to have opposing effects on behavior, in part, by antagonistically regulating transcription of specific genes.
Title: Regulation of serotonin biosynthesis by the G proteins Galphao and Galphaq controls serotonin signaling in Caenorhabditis elegans.
The GAR-3(mAChR)/G alpha(q) pathway sensitizes the spicule neurons and muscles before and during mating so that the male can respond to hermaphrodite vulva efficiently.
Title: G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior.
down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis
Title: Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.
Results demonstrate the existence of a novel pathway for promoting epidermal growth factor-mediated vulval development that involves activation of the heterotrimeric Galphaq protein, EGL-30.
Title: Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01D7.7 (e-PCR)
- UniSTS:319522

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defecation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Guanine nucleotide-binding protein subunit alpha

NP_001293357.1

Confirmed by transcript evidence

NP_001379826.1

Confirmed by transcript evidence

NP_740789.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

1835661..1841965

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170806.6 → NP_740789.1 Guanine nucleotide-binding protein subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740789.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EGU1

Conserved Domains (2) summary

cd00066
Location:34 → 349

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:13 → 353

G_alpha; G protein alpha subunit
NM_001392988.1 → NP_001379826.1 Guanine nucleotide-binding protein subunit alpha [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8T3G5

Conserved Domains (1) summary

cd00066
Location:1 → 297

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_001306428.3 → NP_001293357.1 Guanine nucleotide-binding protein subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293357.1

Status: REVIEWED

UniProtKB/TrEMBL

X5LQ30

Conserved Domains (1) summary

cl38936
Location:1 → 106

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases