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hum-7 Unconventional myosin-IXa-like [ Caenorhabditis elegans ]

Gene ID: 171650, updated on 2-Nov-2024

Summary

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Official Symbol
hum-7
Official Full Name
Unconventional myosin-IXa-like
Primary source
WormBase:WBGene00002040
Locus tag
CELE_F56A6.2
See related
AllianceGenome:WB:WBGene00002040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity and plus-end directed microfilament motor activity. Involved in actin-myosin filament sliding. Predicted to be part of myosin complex. Predicted to be active in actin filament. Is expressed in accessory cell; body wall musculature; and pharynx. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to several human genes including MYO9A (myosin IXA). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hum-7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
30
Sequence:
Chromosome: I; NC_003279.8 (585807..607571, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Crossover junction endonuclease MUS81;ERCC4 domain-containing protein Neighboring gene Piwi domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Head of myosin IX binds calmodulin and moves processively toward the plus-end of actin filaments. Liao W, et al. J Biol Chem, 2010 Aug 6. PMID 20538589, Free PMC Article
  2. The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans. Wallace AG, et al. Development, 2018 Dec 3. PMID 30389847, Free PMC Article
  3. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RHO-1 activity is regulated by SAX-3/ROBO acting on the RhoGAP HUM-7.
    Title: The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
  
enables plus-end directed microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin-myosin filament sliding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Unconventional myosin-IXa-like
NP_001248879.1
  • Confirmed by transcript evidence
NP_001248880.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    585807..607571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261951.3 → NP_001248880.1  Unconventional myosin-IXa-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001248880.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0IWT2
    Conserved Domains (5) summary
    smart00242
    Location:163 → 936
    MYSc; Myosin. Large ATPases
    smart00314
    Location:28 → 134
    RA; Ras association (RalGDS/AF-6) domain
    cd00029
    Location:1475 → 1523
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:181 → 936
    MYSc_Myo9; class IX myosin, motor domain
    cl02570
    Location:1540 → 1727
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_001261950.4 → NP_001248879.1  Unconventional myosin-IXa-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001248879.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L082
    Conserved Domains (5) summary
    smart00242
    Location:163 → 936
    MYSc; Myosin. Large ATPases
    smart00314
    Location:28 → 134
    RA; Ras association (RalGDS/AF-6) domain
    cd00029
    Location:1462 → 1510
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01385
    Location:181 → 936
    MYSc_Myo9; class IX myosin, motor domain
    cl02570
    Location:1527 → 1714
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Nucleotide Protein
Heading Accession and Version

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