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Epcam epithelial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 171577, updated on 30-Mar-2024

Summary

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Official Symbol
Epcamprovided by RGD
Official Full Name
epithelial cell adhesion moleculeprovided by RGD
Primary source
RGD:621365
See related
Ensembl:ENSRNOG00000015667 AllianceGenome:RGD:621365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Egp314; Tacstd1
Summary
Enables cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Is integral component of membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1135.4), Lung (RPKM 204.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Epcam in Genome Data Viewer
Location:
6q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12633715..12649678, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (6880142..6896103, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11282194..11308870, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene uncharacterized LOC120103460 Neighboring gene mutS homolog 2 Neighboring gene uncharacterized LOC120103461 Neighboring gene ribosomal protein S15a, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. EpCAM is decreased but is still present in uterine epithelial cells during early pregnancy in the rat: potential mechanism for maintenance of mucosal integrity during implantation. Poon CE, et al. Cell Tissue Res, 2015 Feb. PMID 25367431
  2. Cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma. Guo Z, et al. World J Gastroenterol, 2014 Feb 28. PMID 24616575, Free PMC Article
  3. Increased expression of epithelial cell adhesion molecule (EpCAM) in rat hepatic tumors induced by diethylnitrosamine. Kang JS. Asian Pac J Cancer Prev, 2012. PMID 23098445
  4. EGP-314 is expressed differentially in three brain zones at an early time in an experimentally induced ischemia rat model. Ortiz-Plata A, et al. Brain Res Mol Brain Res, 2005 Jun 13. PMID 15950761
  5. Metastasis-association of the rat ortholog of the human epithelial glycoprotein antigen EGP314. Würfel J, et al. Oncogene, 1999 Apr 8. PMID 10327052

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that, prior to implantation, EpCAM mediates intercellular adhesion in the uterine epithelium.
    Title: EpCAM is decreased but is still present in uterine epithelial cells during early pregnancy in the rat: potential mechanism for maintenance of mucosal integrity during implantation.
  2. cld7 supports tumorigenic features of EpC by provoking EpC cleavage and thereby its cotranscription factor activity
    Title: EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer.
  3. EpCAM overexpression is asociated with hepatic tumors.
    Title: Increased expression of epithelial cell adhesion molecule (EpCAM) in rat hepatic tumors induced by diethylnitrosamine.
  4. An association between Tacstd1/EpCam and claudin-7 is noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract.
    Title: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadherin binding involved in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding involved in cell-cell adhesion IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
  
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
epithelial cell adhesion molecule
Names
ep-CAM
epithelial glycoprotein 314
tumor-associated calcium signal transducer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138541.2 → NP_612550.1  epithelial cell adhesion molecule precursor

    See identical proteins and their annotated locations for NP_612550.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    O55159
    UniProtKB/TrEMBL
    A0A8I5YCG2
    Related
    ENSRNOP00000021135.5, ENSRNOT00000021135.7
    Conserved Domains (1) summary
    cd00191
    Location:65 → 125
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    12633715..12649678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55159.1 GenPept UniProtKB/Swiss-Prot:O55159

Gene LinkOut

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