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Dnm3 dynamin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171574, updated on 14-Nov-2024

Summary

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Official Symbol
Dnm3provided by RGD
Official Full Name
dynamin 3provided by RGD
Primary source
RGD:727949
See related
EnsemblRapid:ENSRNOG00000026490 AllianceGenome:RGD:727949
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
dynamin-2
Summary
Enables G protein-coupled glutamate receptor binding activity; GTPase activity; and enzyme binding activity. A structural constituent of postsynapse. Involved in several processes, including filopodium assembly; positive regulation of synaptic vesicle recycling; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including dendritic spine head; postsynaptic density; and synaptic cleft. Part of apical tubulobulbar complex and basal tubulobulbar complex. Is active in glutamatergic synapse and postsynaptic endocytic zone membrane. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 130.7), Adrenal (RPKM 65.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnm3 in Genome Data Viewer
Location:
13q22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (76892381..77371346, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74359043..74838135, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79906711..80379967, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692015 Neighboring gene similar to human chromosome 1 open reading frame 105 Neighboring gene uncharacterized LOC102554129 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene microRNA 199a-2 Neighboring gene microRNA 3120 Neighboring gene microRNA 214 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102554073 Neighboring gene uncharacterized LOC102555077 Neighboring gene protein CEBPZOS-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis. Nakata T, et al. J Cell Sci, 1993 May. PMID 8360266
  2. Three dynamin-encoding genes are differentially expressed in developing rat brain. Cook T, et al. J Neurochem, 1996 Sep. PMID 8752097
  3. A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism. Arnold AM, et al. Int J Dev Neurosci, 2003 Aug. PMID 12850060
  4. The cytosolic domain of APP induces the relocalization of dynamin 3 in hippocampal neurons. Meckler X, et al. Eur J Neurosci, 2006 Nov. PMID 17100832
  5. Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis. Li J, et al. Int J Cardiol, 2013 Oct 3. PMID 23410488

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic death of cardiomyocyte.
    Title: Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis.
  2. dynamin isoforms select appropriate vesicle reuse pathways associated with specific neuronal firing patterns
    Title: Dynamin isoforms decode action potential firing for synaptic vesicle recycling.
  3. These results strongly suggest that dynamin 2 is involved in actin dynamics and the formation of dynamin 2-positive ruffles during phagocytosis.
    Title: Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells.
  4. an enhanced interaction between a specific Dyn3 splice variant and cortactin modulate actin-membrane dynamics in developing neurons to regulate the morphogenesis of dendritic spines
    Title: A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines.
  5. Our findings are consistent with the conclusion that dynamin 3 is involved with tubulobulbar morphogenesis.
    Title: The role of dynamin 3 in the testis.
  6. identified a novel dynamin III mRNA that was up-regulated in the hypothyroid state; the 7.2 kb dynamin III transcript is brain-specific and selectively regulated by thyroid hormone status.
    Title: A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitric-oxide synthase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables type 1 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type 5 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm ejaculation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of apical tubulobulbar complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
part_of basal tubulobulbar complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendritic spine head IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dynamin-3
Names
T-dynamin
dynamin, testicular
testicular dynamin
NP_612547.1
XP_006250203.1
XP_006250204.1
XP_038946240.1
XP_038946241.1
XP_038946244.1
XP_063128083.1
XP_063128084.1
XP_063128085.1
XP_063128086.1
XP_063128087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138538.2 → NP_612547.1  dynamin-3

    See identical proteins and their annotated locations for NP_612547.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q08877, Q9QXL9
    UniProtKB/TrEMBL
    A0A8I6A9X4
    Related
    ENSRNOP00000063767.1, ENSRNOT00000067653.5
    Conserved Domains (6) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 744
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam04554
    Location:769 → 832
    Extensin_2; Extensin-like region
    cd01256
    Location:526 → 635
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    76892381..77371346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272014.1 → XP_063128084.1  dynamin-3 isoform X3

    Related
    ENSRNOP00000084111.2, ENSRNOT00000102382.2

  2. XM_063272015.1 → XP_063128085.1  dynamin-3 isoform X5

    Related
    ENSRNOP00000088404.1, ENSRNOT00000104847.2

  3. XM_006250141.5 → XP_006250203.1  dynamin-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9X4
    Conserved Domains (6) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 734
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam04554
    Location:759 → 822
    Extensin_2; Extensin-like region
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 735
    GED; Dynamin GTPase effector domain

  4. XM_006250142.5 → XP_006250204.1  dynamin-3 isoform X4

    See identical proteins and their annotated locations for XP_006250204.1

    UniProtKB/TrEMBL
    A0A8I6A9X4
    Conserved Domains (6) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:79 → 734
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 735
    GED; Dynamin GTPase effector domain
    pfam10630
    Location:749 → 837
    DUF2476; Protein of unknown function (DUF2476)

  5. XM_063272013.1 → XP_063128083.1  dynamin-3 isoform X2

    Related
    ENSRNOP00000068044.2, ENSRNOT00000075938.3

  6. XM_063272017.1 → XP_063128087.1  dynamin-3 isoform X7

  7. XM_063272016.1 → XP_063128086.1  dynamin-3 isoform X6

  8. XM_039090312.2 → XP_038946240.1  dynamin-3 isoform X8

    Conserved Domains (2) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region

  9. XM_039090313.2 → XP_038946241.1  dynamin-3 isoform X8

    Conserved Domains (2) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region

  10. XM_039090316.2 → XP_038946244.1  dynamin-3 isoform X9

    Conserved Domains (2) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    pfam01031
    Location:216 → 498
    Dynamin_M; Dynamin central region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08877.2 GenPept UniProtKB/Swiss-Prot:Q08877

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