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A3galt2 alpha 1,3-galactosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171553, updated on 17-Aug-2024

Summary

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Official Symbol
A3galt2provided by RGD
Official Full Name
alpha 1,3-galactosyltransferase 2provided by RGD
Primary source
RGD:727913
See related
EnsemblRapid:ENSRNOG00000005935 AllianceGenome:RGD:727913
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Involved in cellular response to manganese ion and lipid glycosylation. Acts upstream of or within glycosphingolipid biosynthetic process. Located in Golgi apparatus and vesicle. Orthologous to human A3GALT2 (alpha 1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 128.1), Uterus (RPKM 93.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See A3galt2 in Genome Data Viewer
Location:
5q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146385725..146398156)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141101329..141113760)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (146933592..146945882)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 12 Neighboring gene polyhomeotic homolog 2 Neighboring gene zinc finger protein 362 Neighboring gene uncharacterized LOC102551009

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids. Keusch JJ, et al. J Biol Chem, 2000 Aug 18. PMID 10854427
  2. UDP-galactose:globotriaosylceramide alpha-galactosyltransferase activity in rat pheochromocytoma (PC12h) cells. Pal S, et al. J Lipid Res, 1992 Mar. PMID 1569388
  3. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. Christiansen D, et al. PLoS Biol, 2008 Jul 15. PMID 18630988, Free PMC Article
  4. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, et al. J Comp Neurol, 2007 Mar 1. PMID 17206613
  5. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, et al. Glycobiology, 2003 May. PMID 12626403

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables alpha-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to manganese ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-1,3-galactosyltransferase 2
Names
iGb3 synthase
iGb3S
isoglobotriaosylceramide synthase
NP_612533.1
XP_038965168.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138524.2 → NP_612533.1  alpha-1,3-galactosyltransferase 2

    See identical proteins and their annotated locations for NP_612533.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061714
    UniProtKB/Swiss-Prot
    A0A4Z3, A2JQW1
    UniProtKB/TrEMBL
    A0A8L2Q356, A6ISF7
    Related
    ENSRNOP00000111458.1, ENSRNOT00000126249.1
    Conserved Domains (1) summary
    cd02515
    Location:67 → 338
    Glyco_transf_6; Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    146385725..146398156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109240.1 → XP_038965168.1  alpha-1,3-galactosyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl11394
    Location:69 → 292
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4Z3.1 GenPept UniProtKB/Swiss-Prot:A0A4Z3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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