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Polk DNA polymerase kappa [ Rattus norvegicus (Norway rat) ]

Gene ID: 171525, updated on 2-Nov-2024

Summary

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Official Symbol
Polkprovided by RGD
Official Full Name
DNA polymerase kappaprovided by RGD
Primary source
RGD:620058
See related
EnsemblRapid:ENSRNOG00000060626 AllianceGenome:RGD:620058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dinb1
Summary
Predicted to enable DNA-directed DNA polymerase activity and molecular adaptor activity. Predicted to be involved in cellular response to UV; error-prone translesion synthesis; and nucleotide-excision repair, DNA gap filling. Predicted to act upstream of or within DNA repair. Predicted to be located in nuclear body and site of DNA damage. Predicted to be active in nucleus. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 54.9), Lung (RPKM 38.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polk in Genome Data Viewer
Location:
2q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (29556831..29616960, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27822228..27882331, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27305718..27364906, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene POC5 centriolar protein Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene ceramide transporter 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Okochi E, et al. Jpn J Cancer Res, 2002 May. PMID 12036445, Free PMC Article
  2. RNA m(6)A methylation regulates the ultraviolet-induced DNA damage response. Xiang Y, et al. Nature, 2017 Mar 23. PMID 28297716, Free PMC Article
  3. DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Schenten D, et al. Eur J Immunol, 2002 Nov. PMID 12555660
  4. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR. DNA Repair (Amst), 2011 Jul 15. PMID 21601536
  5. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Ogi T, et al. Mol Cell, 2010 Mar 12. PMID 20227374

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair, DNA gap filling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA polymerase kappa
Names
DNA-directed DNA polymerase kappa
polymerase (DNA directed) kappa
polymerase (DNA) kappa
XP_038957600.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433859.1 → NP_001420788.1  DNA polymerase kappa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  2. NM_138516.2 → NP_612525.2  DNA polymerase kappa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000073092.2, ENSRNOT00000078639.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    29556831..29616960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101672.2 → XP_038957600.1  DNA polymerase kappa isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY51, A0A0G2K4L7, A6I508
    Conserved Domains (2) summary
    smart00734
    Location:760 → 786
    ZnF_Rad18; Rad18-like CCHC zinc finger
    cd03586
    Location:103 → 513
    PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
Nucleotide Protein Strain
Heading Accession and Version

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