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Exoc2 exocyst complex component 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171455, updated on 2-Nov-2024

Summary

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Symbol
Exoc2provided by RGD
Full Name
exocyst complex component 2provided by RGD
Primary source
RGD:619961
See related
EnsemblRapid:ENSRNOG00000060266 AllianceGenome:RGD:619961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rsec5; Sec5l1
Summary
Predicted to enable protein kinase binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; regulation of entry of bacterium into host cell; and vesicle docking involved in exocytosis. Part of exocyst. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 188.9), Lung (RPKM 164.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Exoc2 in Genome Data Viewer
Location:
17p12
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (33714949..33906901)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (33506289..33698246)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (34665810..34842266)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694077 Neighboring gene ribosomal protein S9, pseudogene 1 Neighboring gene ribosomal protein S11, pseudogene 4 Neighboring gene uncharacterized LOC120097838 Neighboring gene HUS1 checkpoint clamp component B Neighboring gene microRNA mir-6319-1 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene interferon regulatory factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. Fukai S, et al. EMBO J, 2003 Jul 1. PMID 12839989, Free PMC Article
  2. Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site. Mott HR, et al. J Biol Chem, 2003 May 9. PMID 12624092
  3. The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Sugihara K, et al. Nat Cell Biol, 2002 Jan. PMID 11744922
  4. Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex. Nichols CD, et al. Curr Biol, 2010 Jul 27. PMID 20579884, Free PMC Article
  5. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Saito T, et al. Biomed Res, 2008 Apr. PMID 18480549

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of entry of bacterium into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of entry of bacterium into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking involved in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  
part_of exocyst ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exocyst complex component 2
Names
exocyst complex component Sec5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134414.2 → NP_599241.2  exocyst complex component 2

    Status: VALIDATED

    Source sequence(s)
    AA875297, AF032666, BP475684, CB582051, CK482593, CO393045, CO396803, DV724419
    UniProtKB/Swiss-Prot
    O54921
    Related
    ENSRNOP00000071882.3, ENSRNOT00000089613.3
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:198 → 377
    Sec5; Exocyst complex component Sec5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    33714949..33906901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095323.2 → XP_038951251.1  exocyst complex component 2 isoform X1

    UniProtKB/TrEMBL
    F1LMB9
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:224 → 400
    Sec5; Exocyst complex component Sec5

  2. XM_039095327.2 → XP_038951255.1  exocyst complex component 2 isoform X5

    UniProtKB/TrEMBL
    F1LMB9
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:224 → 400
    Sec5; Exocyst complex component Sec5

  3. XM_039095324.2 → XP_038951252.1  exocyst complex component 2 isoform X2

    UniProtKB/TrEMBL
    F1LMB9
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:224 → 400
    Sec5; Exocyst complex component Sec5

  4. XM_039095320.2 → XP_038951248.1  exocyst complex component 2 isoform X1

    UniProtKB/TrEMBL
    F1LMB9
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:224 → 400
    Sec5; Exocyst complex component Sec5

  5. XM_039095325.2 → XP_038951253.1  exocyst complex component 2 isoform X3

    UniProtKB/TrEMBL
    F1LMB9
    Related
    ENSRNOP00000072436.2, ENSRNOT00000077110.3
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:200 → 376
    Sec5; Exocyst complex component Sec5

  6. XM_006253891.3 → XP_006253953.1  exocyst complex component 2 isoform X4

    See identical proteins and their annotated locations for XP_006253953.1

    UniProtKB/Swiss-Prot
    O54921
    UniProtKB/TrEMBL
    A0A0G2K416
    Related
    ENSRNOP00000072864.2, ENSRNOT00000090706.3
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:222 → 401
    Sec5; Exocyst complex component Sec5

  7. XM_063276039.1 → XP_063132109.1  exocyst complex component 2 isoform X6

    Related
    ENSRNOP00000111482.1, ENSRNOT00000155008.1

  8. XM_063276041.1 → XP_063132111.1  exocyst complex component 2 isoform X8

  9. XM_063276040.1 → XP_063132110.1  exocyst complex component 2 isoform X7

  10. XM_039095321.2 → XP_038951249.1  exocyst complex component 2 isoform X1

    UniProtKB/TrEMBL
    F1LMB9
    Conserved Domains (2) summary
    pfam01833
    Location:8 → 91
    TIG; IPT/TIG domain
    pfam15469
    Location:224 → 400
    Sec5; Exocyst complex component Sec5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54921.1 GenPept UniProtKB/Swiss-Prot:O54921

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