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Gprasp1 G protein-coupled receptor associated sorting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171407, updated on 17-Aug-2024

Summary

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Official Symbol
Gprasp1provided by RGD
Official Full Name
G protein-coupled receptor associated sorting protein 1provided by RGD
Primary source
RGD:621343
See related
EnsemblRapid:ENSRNOG00000049985 AllianceGenome:RGD:621343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
pips
Summary
Predicted to be involved in G protein-coupled receptor catabolic process and endosome to lysosome transport. Located in cytoplasm and nucleus. Orthologous to human GPRASP1 (G protein-coupled receptor associated sorting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 532.1), Adrenal (RPKM 81.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
Xq32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (103556493..103564275)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (98764853..98772685)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (106306795..106313904)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 5 Neighboring gene RAB18, member RAS oncogene family, pseudogene 1 Neighboring gene ribosomal protein S9, pseudogene 8 Neighboring gene G protein-coupled receptor associated sorting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival. Kiyama A, et al. Biochem Biophys Res Commun, 2006 Jan 13. PMID 16298334
  2. The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength. Sumová A, et al. Brain Res, 2002 Aug 30. PMID 12176169
  3. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Bartlett SE, et al. Proc Natl Acad Sci U S A, 2005 Aug 9. PMID 16049099, Free PMC Article
  4. A novel protein interacts with a clock-related protein, rPer1. Matsuki T, et al. Brain Res, 2001 Oct 19. PMID 11597585
  5. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. Tischkau SA, et al. J Biol Chem, 2003 Jan 10. PMID 12409294

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Per1 gene product in the rat suprachiasmatic nucleus is modulated by seasonal changes in daylength.
    Title: The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength.
  2. Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock
    Title: Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock.
  3. nuclear translocation of PIPS is involved in NGF mediated neuronal survival via TrkA, PI3K, and Gab1 signaling pathway
    Title: Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within G protein-coupled receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor-associated sorting protein 1
Names
GASP-1
Per1 interacting protein
per1-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134386.2 → NP_599213.2  G-protein coupled receptor-associated sorting protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q920R4
    UniProtKB/TrEMBL
    A6KT36, M0R9R0
    Related
    ENSRNOP00000066239.1, ENSRNOT00000073661.4
    Conserved Domains (1) summary
    pfam04826
    Location:1096 → 1341
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    103556493..103564275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279769.1 → XP_063135839.1  G-protein coupled receptor-associated sorting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q920R4
    UniProtKB/TrEMBL
    A6KT36, M0R9R0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920R4.1 GenPept UniProtKB/Swiss-Prot:Q920R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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