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ZNF675 zinc finger protein 675 [ Homo sapiens (human) ]

Gene ID: 171392, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF675provided by HGNC
Official Full Name
zinc finger protein 675provided by HGNC
Primary source
HGNC:HGNC:30768
See related
Ensembl:ENSG00000197372 MIM:620090; AllianceGenome:HGNC:30768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIZ; TBZF
Summary
Enables ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of osteoclast differentiation; negative regulation of signal transduction; and regulation of transcription, DNA-templated. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 3.0), testis (RPKM 2.9) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23652801..23687212, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23792325..23826770, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23835603..23870014, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 29 Neighboring gene vomeronasal 1 receptor 93 pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:23848667-23849407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23868450-23869420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14394 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23906366-23907280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23941373-23941891 Neighboring gene vomeronasal 1 receptor 94 pseudogene Neighboring gene zinc finger protein 681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23944886-23945526 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23945527-23946168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23951857-23952358 Neighboring gene ribosomal protein SA 2 Neighboring gene BCL2 interacting protein 3 pseudogene 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapa. Kimura R, et al. Plant J, 2002 Jan. PMID 11851921
  2. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. Shin JN, et al. J Biol Chem, 2002 Mar 8. PMID 11751921
  3. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the novel zinc finger protein TIZ may play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
    Title: A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36350

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone resorption TAS
Traceable Author Statement
more info
 PubMed 
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 675
Names
TRAF6 inhibitory zinc finger
TRAF6-binding zinc finger protein
TRAF6-inhibitory zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138330.3 → NP_612203.2  zinc finger protein 675

    See identical proteins and their annotated locations for NP_612203.2

    Status: VALIDATED

    Source sequence(s)
    AC073544, DA777369
    Consensus CDS
    CCDS32981.1
    UniProtKB/Swiss-Prot
    Q8N211, Q8TD23
    Related
    ENSP00000352836.3, ENST00000359788.9
    Conserved Domains (6) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:169 → 556
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:314 → 334
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:174 → 194
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:494 → 519
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23652801..23687212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438379.1 → XP_047294335.1  zinc finger protein 675 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23792325..23826770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320136.1 → XP_054176111.1  zinc finger protein 675 isoform X1

  2. XM_054320135.1 → XP_054176110.1  zinc finger protein 675 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TD23.3 GenPept UniProtKB/Swiss-Prot:Q8TD23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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