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Eef1a1 eukaryotic translation elongation factor 1 alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171361, updated on 28-Oct-2024

Summary

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Official Symbol
Eef1a1provided by RGD
Official Full Name
eukaryotic translation elongation factor 1 alpha 1provided by RGD
Primary source
RGD:67387
See related
EnsemblRapid:ENSRNOG00000009439 AllianceGenome:RGD:67387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SI; EF1A; EEF-1; EEF1A; Eef1a2; Eef1a2l1
Summary
Enables heterocyclic compound binding activity; identical protein binding activity; and mRNA binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and regulation of postsynaptic specialization assembly. Is active in GABA-ergic synapse and postsynapse. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Spleen (RPKM 26871.9), Thymus (RPKM 23830.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eef1a1 in Genome Data Viewer
Location:
8q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (88221839..88225688, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79341554..79344784, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85838594..85841816, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 43 Neighboring gene trafficking protein particle complex subunit 14 like 1 Neighboring gene cyclic GMP-AMP synthase Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene uncharacterized LOC134480209 Neighboring gene solute carrier family 17 member 5 Neighboring gene cytochrome c, somatic-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. Hashimoto K, et al. PLoS One, 2011 Mar 1. PMID 21390260, Free PMC Article
  2. Presence of translation elongation factor-1A (eEF1A) in the excitatory postsynaptic density of rat cerebral cortex. Cho SJ, et al. Neurosci Lett, 2004 Aug 5. PMID 15265584
  3. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. Tsokas P, et al. J Neurosci, 2005 Jun 15. PMID 15958750, Free PMC Article
  4. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Borradaile NM, et al. Mol Biol Cell, 2006 Feb. PMID 16319173, Free PMC Article
  5. Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop. Mickleburgh I, et al. RNA, 2006 Jul. PMID 16723660, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eEF1alpha-cytoskeleton interactions play a role in perinuclear mRNA localization.
    Title: Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.
  2. Glutamate exerts an exquisite time-dependent translational control in glial cells, a process that might be critical for glia-neuron interactions in Bergmann glial cells.
    Title: Glutamate regulates eEF1A phosphorylation and ribosomal transit time in Bergmann glial cells.
  3. 5-bp internal stem in the metallothionein-1 3'UTR is critical for binding of eEF1alpha and histidine-tRNA ligase, and that binding of eEF1alpha is facilitated through domains I and III.
    Title: Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA.
  4. EF and GAPDH were identified as the most stable reference genes in auditory cortex and cochlea, respectively.
    Title: Identifying stable reference genes for evaluation of antioxidative enzyme gene expression in auditory cortex and cochlea of young and old Fischer 344 rats.
  5. eEF1A is coupled to both inhibitory and excitatory receptors, in a process that may involve the ERK-signaling pathway
    Title: Components of the translational machinery are associated with juvenile glycine receptors and are redistributed to the cytoskeleton upon aging and synaptic activity.
  6. eEF1A is enriched in the rat cerebellar postsynaptic density (PSD) fraction and is tightly associated with the PSD 'core', colocalizing with the PSD marker PSD95 in dissociated cerebellar cultures and immunoelectron microscopy of adult rat cerebellum.
    Title: Presence of translation elongation factor-1A in the rat cerebellar postsynaptic density.
  7. mRNA for eEF1A is present in pyramidal cell dendrites and that the LTP-associated increase in eEF1A expression was intact in dendrites that had been severed from their cell bodies.
    Title: Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.
  8. stimulation of translation by nerve growth factor
    Title: Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells.
  9. novel role for M4 (Chrm4) in the regulation of protein synthesis through its interaction with eEF1A2.
    Title: Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125172

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables heterocyclic compound binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic specialization assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic specialization assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane TAS
Traceable Author Statement
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongation factor 1-alpha 1
Names
EF-1 alpha2
EF-1-alpha-1
EF-Tu
eEF1A-1
elongation factor 1 A-1
elongation factor Tu
eukaryotic elongation factor 1 A-1
eukaryotic translation elongation factor 1 alpha 2 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175838.2 → NP_787032.1  elongation factor 1-alpha 1

    See identical proteins and their annotated locations for NP_787032.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P62630, Q5BJW8, Q64718, Q78ED4
    UniProtKB/TrEMBL
    A0A8L2Q996, A6I1K3
    Related
    ENSRNOP00000013608.4, ENSRNOT00000013608.8
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 460
    PTZ00141; elongation factor 1- alpha; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    88221839..88225688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264828.1 → XP_063120898.1  elongation factor 1-alpha 1 isoform X1

    UniProtKB/Swiss-Prot
    P62630, Q5BJW8, Q64718, Q78ED4
    UniProtKB/TrEMBL
    A6I1K3

  2. XM_063264829.1 → XP_063120899.1  elongation factor 1-alpha 1 isoform X1

    UniProtKB/Swiss-Prot
    P62630, Q5BJW8, Q64718, Q78ED4
    UniProtKB/TrEMBL
    A6I1K3

  3. XM_039080748.2 → XP_038936676.1  elongation factor 1-alpha 1 isoform X1

    UniProtKB/Swiss-Prot
    P62630, Q5BJW8, Q64718, Q78ED4
    UniProtKB/TrEMBL
    A0A8L2Q996, A6I1K3
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 460
    PTZ00141; elongation factor 1- alpha; Provisional

  4. XM_039080749.2 → XP_038936677.1  elongation factor 1-alpha 1 isoform X1

    UniProtKB/Swiss-Prot
    P62630, Q5BJW8, Q64718, Q78ED4
    UniProtKB/TrEMBL
    A0A8L2Q996, A6I1K3
    Conserved Domains (1) summary
    PTZ00141
    Location:1 → 460
    PTZ00141; elongation factor 1- alpha; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62630.1 GenPept UniProtKB/Swiss-Prot:P62630

Gene LinkOut

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