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Arhgap4 Rho GTPase activating protein 4 [ Mus musculus (house mouse) ]

Gene ID: 171207, updated on 28-Oct-2024

Summary

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Official Symbol
Arhgap4provided by MGI
Official Full Name
Rho GTPase activating protein 4provided by MGI
Primary source
MGI:MGI:2159577
See related
Ensembl:ENSMUSG00000031389 AllianceGenome:MGI:2159577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c1; Rgc1; mKIAA0131; A130009C12Rik; A530015A20Rik
Summary
Predicted to enable GTPase activator activity and identical protein binding activity. Predicted to be involved in negative regulation of axon extension and negative regulation of fibroblast migration. Predicted to be located in several cellular components, including growth cone; microtubule; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in thymus adult (RPKM 79.1), spleen adult (RPKM 57.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap4 in Genome Data Viewer
Location:
X A7.3; X 37.45 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72937958..72954945, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73894352..73911345, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_47357 Neighboring gene predicted gene, 23615 Neighboring gene STARR-seq mESC enhancer starr_47358 Neighboring gene STARR-seq mESC enhancer starr_47359 Neighboring gene L1 cell adhesion molecule Neighboring gene arginine vasopressin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71157031-71157252 Neighboring gene STARR-seq mESC enhancer starr_47360 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p115 Rho GTPase activating protein interacts with MEKK1. Christerson LB, et al. J Cell Physiol, 2002 Aug. PMID 12115726
  2. Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules. Foletta VC, et al. Brain Res Mol Brain Res, 2002 Oct 30. PMID 12414125
  3. PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein. Bai Y, et al. J Biol Chem, 2011 Dec 9. PMID 22009749, Free PMC Article
  4. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
    Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
  2. The p115 Rho GAP binds to MEKK1 in vitro and in intact cells. Expression of p115 Rho GAP reduces MEKK1-induced signaling to AP-1.
    Title: p115 Rho GTPase activating protein interacts with MEKK1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC124367, MGC124368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 4
Names
GTPase-activating protein p115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162423.1 → NP_001155895.1  rho GTPase-activating protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK028789, AK040687, AL672002
    Consensus CDS
    CCDS53101.1
    UniProtKB/TrEMBL
    B1AUY2, Q32MS4
    Related
    ENSMUSP00000110046.2, ENSMUST00000114404.8
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 690
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:748 → 802
    SH3; Src Homology 3 domain superfamily

  2. NM_001162424.1 → NP_001155896.1  rho GTPase-activating protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001155896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AK028789, AK040687, AL672002
    Consensus CDS
    CCDS53100.1
    UniProtKB/TrEMBL
    B1AUX5, Q8VHL8
    Related
    ENSMUSP00000110049.3, ENSMUST00000114407.9
    Conserved Domains (3) summary
    cd07656
    Location:26 → 271
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:493 → 680
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:738 → 792
    SH3; Src Homology 3 domain superfamily

  3. NM_138630.2 → NP_619536.2  rho GTPase-activating protein 4 isoform 1

    See identical proteins and their annotated locations for NP_619536.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK028789, AK040687, AL672002
    Consensus CDS
    CCDS41014.1
    UniProtKB/TrEMBL
    Q80Z68, Q8VHL8
    Related
    ENSMUSP00000067477.7, ENSMUST00000064376.13
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:759 → 813
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72937958..72954945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247535.4 → XP_011245837.1  rho GTPase-activating protein 4 isoform X6

    UniProtKB/TrEMBL
    Q3TE27
    Related
    ENSMUSP00000110048.3, ENSMUST00000114406.9
    Conserved Domains (4) summary
    COG1196
    Location:141 → 377
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl02570
    Location:401 → 588
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:30 → 242
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:652 → 706
    SH3; Src Homology 3 domain superfamily

  2. XM_011247531.4 → XP_011245833.1  rho GTPase-activating protein 4 isoform X2

    UniProtKB/TrEMBL
    Q8VHL8
    Conserved Domains (3) summary
    cd07656
    Location:26 → 292
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:514 → 701
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:765 → 819
    SH3; Src Homology 3 domain superfamily

  3. XM_011247533.4 → XP_011245835.1  rho GTPase-activating protein 4 isoform X4

    UniProtKB/TrEMBL
    Q8VHL8
    Conserved Domains (3) summary
    cd07656
    Location:30 → 275
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:497 → 684
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:748 → 802
    SH3; Src Homology 3 domain superfamily

  4. XM_011247530.3 → XP_011245832.1  rho GTPase-activating protein 4 isoform X1

    UniProtKB/TrEMBL
    Q8VHL8
    Conserved Domains (3) summary
    cd07656
    Location:30 → 296
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:518 → 705
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:769 → 823
    SH3; Src Homology 3 domain superfamily

  5. XM_011247532.4 → XP_011245834.1  rho GTPase-activating protein 4 isoform X3

    UniProtKB/TrEMBL
    Q8VHL8
    Conserved Domains (3) summary
    cd07656
    Location:30 → 296
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:518 → 705
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:763 → 817
    SH3; Src Homology 3 domain superfamily

  6. XM_011247534.4 → XP_011245836.1  rho GTPase-activating protein 4 isoform X5

    UniProtKB/TrEMBL
    Q8VHL8
    Conserved Domains (3) summary
    cd07656
    Location:3 → 269
    F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
    cl02570
    Location:491 → 678
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:742 → 796
    SH3; Src Homology 3 domain superfamily

  7. XM_011247536.4 → XP_011245838.1  rho GTPase-activating protein 4 isoform X7

    UniProtKB/TrEMBL
    Q8BM00
    Conserved Domains (2) summary
    cl02570
    Location:165 → 352
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:416 → 470
    SH3; Src Homology 3 domain superfamily

  8. XM_011247537.3 → XP_011245839.1  rho GTPase-activating protein 4 isoform X8

    UniProtKB/TrEMBL
    Q8BM00
    Conserved Domains (2) summary
    cl02570
    Location:152 → 339
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl17036
    Location:403 → 457
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
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