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Pank4 pantothenate kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171053, updated on 17-Aug-2024

Summary

Official Symbol
Pank4provided by RGD
Official Full Name
pantothenate kinase 4provided by RGD
Primary source
RGD:628857
See related
EnsemblRapid:ENSRNOG00000014044 AllianceGenome:RGD:628857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fang1
Summary
Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 144.1), Heart (RPKM 137.3) and 9 other tissues See more
Orthologs
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Genomic context

See Pank4 in Genome Data Viewer
Location:
5q36
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (170807744..170824478)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (165525340..165542139)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172367593..172384077)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin like 2B Neighboring gene TNF receptor superfamily member 14 Neighboring gene hes family bHLH transcription factor 5 Neighboring gene phospholipase C, eta 2 Neighboring gene peroxisomal biogenesis factor 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pantothenate kinase activity IEA
Inferred from Electronic Annotation
more info
 
NOT enables pantothenate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
4'-phosphopantetheine phosphatase
Names
hypothetical protein Fang1
inactive pantothenic acid kinase 4
pantothenate kinase 4 (inactive)
pantothenic acid kinase 4
rPanK4
NP_598215.1
XP_063143183.1
XP_063143184.1
XP_063143185.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133531.2NP_598215.1  4'-phosphopantetheine phosphatase

    See identical proteins and their annotated locations for NP_598215.1

    Status: PROVISIONAL

    Source sequence(s)
    AF399873
    UniProtKB/Swiss-Prot
    Q923S8
    UniProtKB/TrEMBL
    A6IUN0, G3V7T3
    Related
    ENSRNOP00000019028.2, ENSRNOT00000019028.6
    Conserved Domains (1) summary
    PLN02902
    Location:17771
    PLN02902; pantothenate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    170807744..170824478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287113.1XP_063143183.1  4'-phosphopantetheine phosphatase isoform X1

  2. XM_063287115.1XP_063143185.1  4'-phosphopantetheine phosphatase isoform X2

  3. XM_063287114.1XP_063143184.1  4'-phosphopantetheine phosphatase isoform X2

RNA

  1. XR_005504359.2 RNA Sequence