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Zfp384 zinc finger protein 384 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171018, updated on 14-Nov-2024

Summary

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Official Symbol
Zfp384provided by RGD
Official Full Name
zinc finger protein 384provided by RGD
Primary source
RGD:708346
See related
EnsemblRapid:ENSRNOG00000017066 AllianceGenome:RGD:708346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ciz; Nmp4; Znf384
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SH3 domain binding activity. Involved in nucleocytoplasmic transport; positive regulation of protein secretion; and positive regulation of transcription by RNA polymerase II. Located in focal adhesion. Orthologous to human ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 120.8), Spleen (RPKM 96.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp384 in Genome Data Viewer
Location:
4q42
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159496481..159526010)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157810263..157840052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157523083..157552606)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102387 Neighboring gene COP9 signalosome subunit 7A Neighboring gene PILR alpha associated neural protein Neighboring gene uncharacterized LOC102554095 Neighboring gene inhibitor of growth family, member 4 Neighboring gene acrosin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Nakamoto T, et al. Mol Cell Biol, 2000 Mar. PMID 10669742, Free PMC Article
  2. Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts. Shah R, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15026307
  3. Osteoblast intracellular localization of Nmp4 proteins. Torrungruang K, et al. Bone, 2002 Jun. PMID 12052465
  4. Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. Thunyakitpisal P, et al. J Bone Miner Res, 2001 Jan. PMID 11149472
  5. Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen. Hayata T, et al. Biochem Biophys Res Commun, 2008 Apr 4. PMID 18211825

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results revealed that Ciz interacts with C-propeptides of type I collagen and this association takes place in nuclei.
    Title: Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen.
  2. Nmp4/CIZ is a component of a multiprotein assemblage or enhanceosome within the MMP-13 parathyroid hormone response region and that, within this context, Nmp4/CIZ promotes both basal expression and hormonal synergy.
    Title: Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts.
  3. localization in the cytoplasm of osteoblasts[Nmp4 - nuclear matrix protein 4]
    Title: Osteoblast intracellular localization of Nmp4 proteins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 384
Names
Cas-associated zinc finger protein
nuclear matrix protein 4
nuclear matrix transcription factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034830.2 → NP_001030002.1  zinc finger protein 384 isoform 1

    See identical proteins and their annotated locations for NP_001030002.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    A0A8J8XAE9, A6ILP2
    Conserved Domains (3) summary
    COG5048
    Location:209 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:243 → 268
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001034831.2 → NP_001030003.1  zinc finger protein 384 isoform 2

    See identical proteins and their annotated locations for NP_001030003.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K403, A6ILP4
    Related
    ENSRNOP00000023242.6, ENSRNOT00000023240.10
    Conserved Domains (3) summary
    COG5048
    Location:209 → 395
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:243 → 268
    zf-H2C2_2; Zinc-finger double domain

  3. NM_133429.3 → NP_596920.2  zinc finger protein 384 isoform 1

    See identical proteins and their annotated locations for NP_596920.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    A0A8J8XAE9, A6ILP2
    Related
    ENSRNOP00000023192.7, ENSRNOT00000023192.9
    Conserved Domains (3) summary
    COG5048
    Location:209 → 409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:243 → 268
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159496481..159526010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285447.1 → XP_063141517.1  zinc finger protein 384 isoform X3

    UniProtKB/TrEMBL
    A0A8J8XAE9, A6ILP2

  2. XM_017592416.3 → XP_017447905.1  zinc finger protein 384 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    D3ZWX3
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017592413.3 → XP_017447902.1  zinc finger protein 384 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    D3ZWX3
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_063285450.1 → XP_063141520.1  zinc finger protein 384 isoform X5

    UniProtKB/TrEMBL
    D4A6Z1, G3V9M5

  5. XM_063285451.1 → XP_063141521.1  zinc finger protein 384 isoform X5

    UniProtKB/TrEMBL
    D4A6Z1, G3V9M5

  6. XM_063285454.1 → XP_063141524.1  zinc finger protein 384 isoform X7

    UniProtKB/TrEMBL
    A6ILP4

  7. XM_006237327.4 → XP_006237389.1  zinc finger protein 384 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    D3ZWX3
    Related
    ENSRNOP00000037592.5, ENSRNOT00000036654.9
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_063285453.1 → XP_063141523.1  zinc finger protein 384 isoform X7

    UniProtKB/TrEMBL
    A6ILP4

  9. XM_063285452.1 → XP_063141522.1  zinc finger protein 384 isoform X6

  10. XM_063285446.1 → XP_063141516.1  zinc finger protein 384 isoform X2

  11. XM_063285448.1 → XP_063141518.1  zinc finger protein 384 isoform X4

    UniProtKB/TrEMBL
    A6ILP5

  12. XM_063285455.1 → XP_063141525.1  zinc finger protein 384 isoform X8

    UniProtKB/TrEMBL
    G3V883

  13. XM_063285456.1 → XP_063141526.1  zinc finger protein 384 isoform X10

  14. XM_017592415.3 → XP_017447904.1  zinc finger protein 384 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    D3ZWX3
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. XM_017592417.3 → XP_017447906.1  zinc finger protein 384 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
    UniProtKB/TrEMBL
    D3ZWX3
    Conserved Domains (2) summary
    COG5048
    Location:285 → 440
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. XM_063285449.1 → XP_063141519.1  zinc finger protein 384 isoform X5

    UniProtKB/TrEMBL
    D4A6Z1, G3V9M5
    Related
    ENSRNOP00000052839.4, ENSRNOT00000055985.7

  17. XM_039106974.2 → XP_038962902.1  zinc finger protein 384 isoform X9

    Conserved Domains (2) summary
    COG5048
    Location:140 → 295
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:206 → 226
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQJ4.1 GenPept UniProtKB/Swiss-Prot:Q9EQJ4

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