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Kcng3 potassium voltage-gated channel modifier subfamily G member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171011, updated on 18-Sep-2024

Summary

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Official Symbol
Kcng3provided by RGD
Official Full Name
potassium voltage-gated channel modifier subfamily G member 3provided by RGD
Primary source
RGD:628832
See related
EnsemblRapid:ENSRNOG00000004535 AllianceGenome:RGD:628832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kv6.3; Kv10.1
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 28.1), Brain (RPKM 18.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcng3 in Genome Data Viewer
Location:
6q12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16803842..16851791)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11051311..11099264)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6794808..6842758, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 3 Neighboring gene uncharacterized LOC134479096 Neighboring gene uncharacterized LOC134479097 Neighboring gene uncharacterized LOC120093197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. Sano Y, et al. FEBS Lett, 2002 Feb 13. PMID 11852086
  2. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera EC. Brain Res Mol Brain Res, 2004 Apr 7. PMID 15046870
  3. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Ottschytsch N, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060745, Free PMC Article
  4. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Mederos Y Schnitzler M, et al. J Biol Chem, 2009 Feb 13. PMID 19074135
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
    Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of potassium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily G member 3
Names
potassium channel, voltage gated modifier subfamily G, member 3
potassium voltage-gated channel, subfamily G, member 3
potassium voltage-gated channel, subfamily G, memeber 3
voltage-gated potassium channel 6.3
voltage-gated potassium channel subunit Kv10.1
voltage-gated potassium channel subunit Kv6.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033957.1 → NP_001029129.1  potassium voltage-gated channel subfamily G member 3 isoform 2

    See identical proteins and their annotated locations for NP_001029129.1

    Status: VALIDATED

    Source sequence(s)
    AF454549
    UniProtKB/Swiss-Prot
    Q8R523
    Conserved Domains (4) summary
    smart00225
    Location:11 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:202 → 406
    Ion_trans; Ion transport protein
    pfam07885
    Location:349 → 394
    Ion_trans_2; Ion channel
    cl02518
    Location:11 → 111
    BTB; BTB/POZ domain

  2. NM_133426.2 → NP_596917.2  potassium voltage-gated channel subfamily G member 3 isoform 1

    See identical proteins and their annotated locations for NP_596917.2

    Status: VALIDATED

    Source sequence(s)
    AF454550
    UniProtKB/Swiss-Prot
    Q8R523
    Related
    ENSRNOP00000006094.4, ENSRNOT00000006094.8
    Conserved Domains (4) summary
    smart00225
    Location:11 → 119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:216 → 417
    Ion_trans; Ion transport protein
    pfam07885
    Location:360 → 405
    Ion_trans_2; Ion channel
    cl02518
    Location:11 → 111
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    16803842..16851791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R523.2 GenPept UniProtKB/Swiss-Prot:Q8R523

Gene LinkOut

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