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Myoz3 myozenin 3 [ Mus musculus (house mouse) ]

Gene ID: 170947, updated on 2-Nov-2024

Summary

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Official Symbol
Myoz3provided by MGI
Official Full Name
myozenin 3provided by MGI
Primary source
MGI:MGI:2179296
See related
Ensembl:ENSMUSG00000049173 AllianceGenome:MGI:2179296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fatz-3; 4833419K08Rik
Summary
Predicted to enable FATZ binding activity; actin binding activity; and telethonin binding activity. Located in Z disc. Is expressed in heart; skeletal muscle; and stomach. Orthologous to human MYOZ3 (myozenin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in mammary gland adult (RPKM 4.7), lung adult (RPKM 0.8) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Myoz3 in Genome Data Viewer
Location:
18 D3; 18 34.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60706789..60724931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60573717..60591716, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene dynactin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9978 Neighboring gene predicted gene, 52358 Neighboring gene RNA binding motif protein 22 Neighboring gene synaptopodin Neighboring gene STARR-seq mESC enhancer starr_44719 Neighboring gene RIKEN cDNA G630071F17 gene Neighboring gene VISTA enhancer mm1623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies. von Nandelstadh P, et al. Mol Cell Biol, 2009 Feb. PMID 19047374, Free PMC Article
  2. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. Frey N, et al. J Biol Chem, 2002 Apr 19. PMID 11842093
  3. Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Liu TY, et al. Open Biol, 2017 Jan. PMID 28077597, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
    Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC123456, MGC123457

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FATZ binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telethonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myozenin-3
Names
FATZ-related protein 3
calsarcin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133363.4 → NP_579941.2  myozenin-3

    Status: VALIDATED

    Source sequence(s)
    AC149216
    Consensus CDS
    CCDS29273.1
    UniProtKB/Swiss-Prot
    Q8R4E4
    UniProtKB/TrEMBL
    E9QJU4
    Related
    ENSMUSP00000063108.8, ENSMUST00000056533.9
    Conserved Domains (1) summary
    pfam05556
    Location:1 → 245
    Calsarcin; Calcineurin-binding protein (Calsarcin)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60706789..60724931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4E4.1 GenPept UniProtKB/Swiss-Prot:Q8R4E4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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